The human connectome in Alzheimer disease—relationship to biomarkers and genetics

M Yu, O Sporns, AJ Saykin - Nature Reviews Neurology, 2021 - nature.com
The pathology of Alzheimer disease (AD) damages structural and functional brain networks,
resulting in cognitive impairment. The results of recent connectomics studies have now …

Connectome-based modelling of neurodegenerative diseases: towards precision medicine and mechanistic insight

JW Vogel, N Corriveau-Lecavalier… - Nature Reviews …, 2023 - nature.com
Neurodegenerative diseases are the most common cause of dementia. Although their
underlying molecular pathologies have been identified, there is substantial heterogeneity in …

Standardizing workflows in imaging transcriptomics with the abagen toolbox

RD Markello, A Arnatkeviciute, JB Poline, BD Fulcher… - elife, 2021 - elifesciences.org
Gene expression fundamentally shapes the structural and functional architecture of the
human brain. Open-access transcriptomic datasets like the Allen Human Brain Atlas provide …

Epilepsy and brain network hubs

J Royer, BC Bernhardt, S Larivière, E Gleichgerrcht… - …, 2022 - Wiley Online Library
Epilepsy is a disorder of brain networks. A better understanding of structural and dynamic
network properties may improve epilepsy diagnosis, treatment, and prognostics. Hubs are …

[HTML][HTML] Comparing spatial null models for brain maps

RD Markello, B Misic - NeuroImage, 2021 - Elsevier
Technological and data sharing advances have led to a proliferation of high-resolution
structural and functional maps of the brain. Modern neuroimaging research increasingly …

[HTML][HTML] Tractography dissection variability: What happens when 42 groups dissect 14 white matter bundles on the same dataset?

KG Schilling, F Rheault, L Petit, CB Hansen, V Nath… - Neuroimage, 2021 - Elsevier
White matter bundle segmentation using diffusion MRI fiber tractography has become the
method of choice to identify white matter fiber pathways in vivo in human brains. However …

[HTML][HTML] TractoFlow: A robust, efficient and reproducible diffusion MRI pipeline leveraging Nextflow & Singularity

G Theaud, JC Houde, A Boré, F Rheault, F Morency… - Neuroimage, 2020 - Elsevier
Diffusion MRI tractography processing pipeline requires a large number of steps (typically
20+ steps). If parameters of these steps, number of threads, and random seed generators …

Toward personalized medicine in connectomic deep brain stimulation

B Hollunder, N Rajamani, SH Siddiqi, C Finke… - Progress in …, 2022 - Elsevier
At the group-level, deep brain stimulation leads to significant therapeutic benefit in a
multitude of neurological and neuropsychiatric disorders. At the single-patient level …

Network structure and transcriptomic vulnerability shape atrophy in frontotemporal dementia

G Shafiei, V Bazinet, M Dadar, AL Manera, DL Collins… - Brain, 2023 - academic.oup.com
Connections among brain regions allow pathological perturbations to spread from a single
source region to multiple regions. Patterns of neurodegeneration in multiple diseases …

Prevalence of white matter pathways coming into a single white matter voxel orientation: The bottleneck issue in tractography

KG Schilling, CMW Tax, F Rheault… - Human brain …, 2022 - Wiley Online Library
Characterizing and understanding the limitations of diffusion MRI fiber tractography is a
prerequisite for methodological advances and innovations which will allow these techniques …