Melatonin is an immune modulator that displays both pro‐and anti‐inflammatory properties.
Proinflammatory actions, which are well documented by many studies in isolated cells or …

Abstract Melatonin (N‐acetyl‐5‐methoxytryptamine), an indoleamine produced in many
organs including the pineal gland, was initially characterized as a hormone primarily …

Melatonin, the neurohormone of the pineal gland, is also produced by various other tissues
and cells. It acts via G protein-coupled receptors expressed in various areas of the central …

Melatonin is the major secretory product synthesized and secreted by the pineal gland and
shows both a wide distribution within phylogenetically distant organisms from bacteria to …

Melatonin is a ubiquitous hormone found in various organisms and highly affects the
function of immune cells. In this review, we summarize the current understanding of the …

The classic theories of aging such as the free radical theory, including its mitochondria‐
related versions, have largely focused on a few specific processes of senescence …

Head and neck squamous cell carcinoma (HNSCC) clearly involves activation of the Akt
mammalian target of rapamycin (mTOR) signalling pathway. However, the effectiveness of …

Melatonin is an uncommonly widely distributed molecule. It is found throughout the plant
and animal kingdoms, ie, perhaps in every living organism. Within vertebrate organisms …

Besides its well‐known regulatory role on circadian rhythm, the pineal gland hormone
melatonin has other biological functions and a distinct metabolism in various cell types and …

Reactive oxygen species (ROS) constitute a group of highly reactive molecules that have
evolved as regulators of important signaling pathways. In this context, tumor cells have an …