Tripartite motif (TRIM) family proteins, most of which have E3 ubiquitin ligase activities, have
various functions in cellular processes including intracellular signaling, development …

Mammalian cells express a variety of innate immune proteins—known as restriction factors—
which defend against invading retroviruses such as HIV-1. Two members of the tripartite …

Tripartite motif (TRIM) proteins constitute one of the largest subfamilies of Really Interesting
New Gene (RING) E3 ubiquitin ligases and contribute to the regulation of numerous cellular …

TRIM proteins form a protein family that is characterized by a conserved tripartite motif
domain comprising a RING domain, one or two B-box domains and a coiled-coil region …

ProMyelocyticLeukemia nuclear bodies (PML NBs) are stress-regulated domains directly
implicated in acute promyelocytic leukemia eradication. Most TRIM family members bind …

The retroviral restriction factor tripartite motif–containing 5α (Trim5α) acts during the early
postentry stages of the retroviral life cycle to block infection by a broad range of retroviruses …

TRIM5α is an E3 ubiquitin ligase of the TRIM family that binds to the capsids of primate
immunodeficiency viruses and blocks viral replication after cell entry. Here we investigate …

Targeted therapy has become increasingly important in cancer therapy. For example,
targeting the promyelocytic leukemia PML protein in leukemia has proved to be an effective …

Transcription of endogenous retroviral elements are tightly regulated during development by
members of the KRAB‐containing zinc finger proteins (KRAB‐ZFPs) and the co‐repressor …

TRIM28 (also known as KAP1 or TIF1β) is the universal co-repressor of the Krüppel-
associated box-containing zinc finger proteins (Krab-ZFPs), the largest family of transcription …