Despite considerable progress in genome-and proteome-based high-throughput screening
methods and in rational drug design, the increase in approved drugs in the past decade did …

Prevalence of cooperation within groups of selfish individuals is puzzling in that it contradicts
with the basic premise of natural selection. Favoring players with higher fitness, the latter is …

Integrative explanations of why obesity is more prevalent in some sectors of the human
population than others are lacking. Here, we outline and evaluate one candidate …

Networks form the backbone of many complex systems, ranging from the Internet to human
societies. Accordingly, not only is the range of our interactions limited and thus best …

Single molecule and NMR measurements of protein dynamics increasingly uncover the
complexity of binding scenarios. Here, we describe an extended conformational selection …

Covering the major topics of evolutionary game theory, Game-Theoretical Models in Biology,
Second Edition presents both abstract and practical mathematical models of real biological …

As the indispensable role of natural microbial communities in many aspects of life on Earth
is uncovered, the bottom-up engineering of synthetic microbial consortia with novel functions …

To be the fittest is central to proliferation in evolutionary games. Individuals thus adopt the
strategies of better performing players in the hope of successful reproduction. In structured …

The Warburg effect-a classical hallmark of cancer metabolism-is a counter-intuitive
phenomenon in which rapidly proliferating cancer cells resort to inefficient ATP production …

Spatially extended population dynamics models that incorporate demographic noise serve
as case studies for the crucial role of fluctuations and correlations in biological systems …