Metabolic reprogramming has been widely recognized as a hallmark of malignancy. The
uptake and metabolism of amino acids are aberrantly upregulated in many cancers that …

Cytotoxic T-lymphocyte–associated antigen-4 (CTLA-4) or programmed death-1 (PD-
1)/programmed death-ligand 1 (PD-L1)–based immune checkpoint inhibitors (ICIs) have led …

Triple negative breast cancer (TNBC) metastases are assumed to exhibit similar functions in
different organs as in the original primary tumor. However, studies of metastasis are often …

Breast cancer (BrCa) is the leading cause of cancer incidence and mortality in women
worldwide. While BrCa treatment has been shown to be highly successful if detected at an …

The kynurenine pathway (KP) is the major catabolic pathway for the essential amino acid
tryptophan leading to he production of nicotinamide adenine dinucleotide. In inflammatory …

Within the growing field of amino acid metabolism, tryptophan (Trp) catabolism is an area of
increasing interest. Trp is essential for protein synthesis, and its metabolism gives rise to …

Purpose Regulatory T cells (Tregs) heavily infiltrate triple-negative breast cancer (TNBC),
and their accumulation is affected by the metabolic reprogramming in cancer cells. In the …

Triple-negative breast cancer (TNBC) is an aggressive malignancy that requires effective
targeted drug therapy. In this study, we employed in silico methods to evaluate the efficacy of …

Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes
diverse clinical manifestations and tissue injuries in multiple organs. However, cellular and …

Weighted correlation network analysis (WGCNA) is a statistical method that has been widely
used in recent years to explore gene co-expression modules. Competing endogenous RNA …