Amyloid oligomers: A joint experimental/computational perspective on Alzheimer's disease, Parkinson's disease, type II diabetes, and amyotrophic lateral sclerosis
PH Nguyen, A Ramamoorthy, BR Sahoo… - Chemical …, 2021 - ACS Publications
Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …
O-GlcNAcylation in health and neurodegenerative diseases
O-GlcNAcylation is a posttranslational modification that adds O-linked β-N-
acetylglucosamine (O-GlcNAc) to serine or threonine residues of many proteins. This protein …
acetylglucosamine (O-GlcNAc) to serine or threonine residues of many proteins. This protein …
Recognition of the amyloid precursor protein by human γ-secretase
INTRODUCTION Alzheimer's disease (AD) is characterized by amyloid plaques in the brains
of patients. The primary components of amyloid plaques are β-amyloid peptides (Aβs) …
of patients. The primary components of amyloid plaques are β-amyloid peptides (Aβs) …
Sampling the conformational space of the catalytic subunit of human γ-secretase
Human γ-secretase is an intra-membrane protease that cleaves many different substrates.
Aberrant cleavage of Notch is implicated in cancer, while abnormalities in cutting amyloid …
Aberrant cleavage of Notch is implicated in cancer, while abnormalities in cutting amyloid …
An atomic structure of human γ-secretase
Dysfunction of the intramembrane protease γ-secretase is thought to cause Alzheimer's
disease, with most mutations derived from Alzheimer's disease mapping to the catalytic …
disease, with most mutations derived from Alzheimer's disease mapping to the catalytic …
Trafficking and proteolytic processing of APP
C Haass, C Kaether… - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
Accumulations of insoluble deposits of amyloid β-peptide are major pathological hallmarks
of Alzheimer disease. Amyloid β-peptide is derived by sequential proteolytic processing from …
of Alzheimer disease. Amyloid β-peptide is derived by sequential proteolytic processing from …
Comparison of ultracentrifugation, density gradient separation, and immunoaffinity capture methods for isolating human colon cancer cell line LIM1863-derived …
Exosomes are 40–100nm extracellular vesicles that are released from a multitude of cell
types, and perform diverse cellular functions including intercellular communication, antigen …
types, and perform diverse cellular functions including intercellular communication, antigen …
Targeting amyloidogenic processing of APP in Alzheimer's disease
Alzheimer's disease (AD) is the most common type of senile dementia, characterized by
neurofibrillary tangle and amyloid plaque in brain pathology. Major efforts in AD drug were …
neurofibrillary tangle and amyloid plaque in brain pathology. Major efforts in AD drug were …
Alzheimer's disease and the amyloid-β peptide
MP Murphy, H LeVine III - Journal of Alzheimer's disease, 2010 - content.iospress.com
Alzheimer's disease (AD) pathogenesis is widely believed to be driven by the production
and deposition of the amyloid-β peptide (Aβ). For many years, investigators have been …
and deposition of the amyloid-β peptide (Aβ). For many years, investigators have been …
[HTML][HTML] The canonical Notch signaling pathway: unfolding the activation mechanism
R Kopan, MXG Ilagan - Cell, 2009 - cell.com
Notch signaling regulates many aspects of metazoan development and tissue renewal.
Accordingly, the misregulation or loss of Notch signaling underlies a wide range of human …
Accordingly, the misregulation or loss of Notch signaling underlies a wide range of human …