As reperfusion therapies have become more widely used in acute myocardial infarction
patients, ischemia-induced myocardial damage has been markedly reduced, but reperfusion …

Acute myocardial infarction is the leading cause of cardiovascular‑related mortality and
chronic heart failure worldwide. As regards treatment, the reperfusion of ischemic tissue …

Despite significant advances in the treatment of myocardial ischemia-reperfusion (I/R) injury,
coronary circulation is a so far neglected target of cardioprotection. In this study, we …

Thrombolytic therapy and revascularization strategies create a complete recanalization of
the occluded epicardial coronary artery in patients with myocardial infarction (MI). However …

Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide.
Metabolic dysfunction is a fundamental core mechanism underlying CVDs. Previous studies …

Objectives Cerebral ischemia/reperfusion (IR) drives oxidative stress and injurious
metabolic processes that lead to redox imbalance, inflammation, and tissue damage …

In the context of myocardial infarction, the burst of superoxide generated by reverse electron
transport (RET) at complex I in mitochondria is a crucial trigger for damage during …

Impaired function of the endoplasmic reticulum (ER) is followed by evolutionarily conserved
cell stress responses, which are employed by cells, including cardiomyocytes, to maintain …

Advances in surgical procedures, technology, and immune suppression have transformed
organ transplantation. However, the metabolic changes that occur during organ retrieval …

Mitochondrial reactive oxygen species (mROS) are routinely produced at several sites within
the organelle. The balance in their formation and elimination is maintained by a complex …