Proliferating cell nuclear antigen (PCNA) plays critical roles in many aspects of DNA
replication and replication-associated processes, including translesion synthesis, error-free …

Background PCNA (proliferating cell nuclear antigen) has been found in the nuclei of yeast,
plant and animal cells that undergo cell division, suggesting a function in cell cycle …

Traditionally, protein–protein interactions were thought to be mediated by large, structured
domains. However, it has become clear that the interactome comprises a wide range of …

Inheritance requires genome duplication, reproduction of chromatin and its epigenetic
information, mechanisms to ensure genome integrity, and faithful transmission of the …

Proliferating cell nuclear antigen (PCNA) was originally characterised as a DNA sliding
clamp for replicative DNA polymerases and as an essential component of the eukaryotic …

From its very beginning, life has faced the fundamental problem that the form in which
genetic information is stored is not chemically inert. DNA integrity is challenged by the …

Over the past few years, media have popularized the story of the “children of the moon” who
must remain in the dark and avoid exposure to sunlight. 1r3 These children suffer from a rare …

Deficiency in repair of nuclear and mitochondrial DNA damage has been linked to several
neurodegenerative disorders. Many recent experimental results indicate that the post-mitotic …

Replication of the two template strands at eukaryotic cell DNA replication forks is a highly
coordinated process that ensures accurate and efficient genome duplication. Biochemical …

Base excision repair (BER) proteins act upon a significantly broad spectrum of DNA lesions
that result from endogenous and exogenous sources. Multiple sub-pathways of BER (short …