Substituted phenothiazines as mitochondrial agents
S Hecht, O Khdour, SR Chowdhury… - US Patent …, 2019 - Google Patents
Yoon, et al.,“Iron-sulfur cluster biosynthesis. Characterization of frataxin as an iron donor for
assembly of [2Fe-2S] clusters in ISU-type proteins”, J. Am. Chem. Soc. 125 (20), 6078-6084 …
assembly of [2Fe-2S] clusters in ISU-type proteins”, J. Am. Chem. Soc. 125 (20), 6078-6084 …
Therapeutic compounds
S Hecht, O Khdour, M Alam, DEY Sriloy… - US Patent …, 2019 - Google Patents
Compounds of formula (I) and salts are disclosed. Also disclosed are isotopes of
compounds of formula I of the salts thereof. Pharmaceutical compositions comprising a com …
compounds of formula I of the salts thereof. Pharmaceutical compositions comprising a com …
Therapeutic compounds
S Hecht, O Khdour, SR Chowdhury… - US Patent …, 2020 - Google Patents
The invention provides compounds having the general for mula I: and pharmaceutically
acceptable salts thereof, wherein the variables R', R2, R3, R1, subscipt m and n, have the …
acceptable salts thereof, wherein the variables R', R2, R3, R1, subscipt m and n, have the …
Prodrug and profluorescent compounds for selective mitochondrial imaging and therapeutic targeting
A Chevalier, O Khdour, Y Zhang, S Hecht - US Patent 10,604,501, 2020 - Google Patents
The present invention relates to the use of prodrugs susceptible to nitroreductase (NTR)
activation. In particular, provided herein are mitochondria-targeting prodrug compounds and …
activation. In particular, provided herein are mitochondria-targeting prodrug compounds and …
Substituted pyrimidine compounds as multifunctional radical quenchers and their uses
S Hecht, O Khdour, A Chevalier - US Patent 11,390,605, 2022 - Google Patents
US11390605B2 - Substituted pyrimidine compounds as multifunctional radical quenchers and
their uses - Google Patents US11390605B2 - Substituted pyrimidine compounds as …
their uses - Google Patents US11390605B2 - Substituted pyrimidine compounds as …
Electrophilic androgen receptor (AR) antagonists for AR downregulation and ferroptosis induction in cancer cells
Z Qin, L Xu - US Patent 12,133,846, 2024 - Google Patents
Alumkal, et al.,“A phase II study of sulforaphane-rich broccoli sprout extracts in men with
recurrent prostate cancer,” Investigational New Drugs, vol. 33, 2015, pp. 480-489. Beer, et …
recurrent prostate cancer,” Investigational New Drugs, vol. 33, 2015, pp. 480-489. Beer, et …
Therapeutic compounds
S Hecht, O Khdour, SR Chowdhury… - US Patent …, 2023 - Google Patents
2021-02-08 Assigned to ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE
UNIVERSITY reassignment ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA …
UNIVERSITY reassignment ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA …
Engineered bacterial ribosome compositions and methods
S Hecht, L Dedkova, S Chen, X Bai - US Patent 12,110,313, 2024 - Google Patents
Compositions and methods relating to bacterial ribosomes selected to increase the
incorporation of at least one glycosylated amino acid into a protein versus a wild-type …
incorporation of at least one glycosylated amino acid into a protein versus a wild-type …
Prodrug and profluorescent compounds for selective mitochondrial imaging and therapeutic targeting
A Chevalier, O Khdour, Y Zhang, S Hecht - US Patent 11,203,583, 2021 - Google Patents
The present invention relates to the use of prodrugs suscep tible to nitroreductase (NTR)
activation. In particular, pro vided herein are mitochondria-targeting prodrug compounds …
activation. In particular, pro vided herein are mitochondria-targeting prodrug compounds …
Substituted phenothiazines as mitochondrial agents
S Hecht, O Khdour, SR Chowdhury… - US Patent …, 2021 - Google Patents
Asin-Cayuela, J, et al.,“Fine-tuning the hydrophobicity of a mitochondria-targeted
antioxidant”, FEBS Lett 571 (1-3), 9-16 (2004). Atamna, H, et al.,“Methylene blue delays …
antioxidant”, FEBS Lett 571 (1-3), 9-16 (2004). Atamna, H, et al.,“Methylene blue delays …