Glioblastoma is one of the most lethal human cancers, with poor survival despite surgery,
radiation treatment, and chemotherapy. Advances in the treatment of this type of brain tumor …

In cancer research, the use of established cell lines has gradually been replaced by primary
cell cultures due to their better representation of in vivo cancer cell behaviors. However, a …

Glioblastomas (GBMs) are aggressive brain tumors characterized by extensive inter-and
intratumor heterogeneity. Patient-derived models, such as organoids and explants, have …

Mutations in codon 132 of isocitrate dehydrogenase (IDH) 1 are frequent in diffuse glioma,
acute myeloid leukemia, chondrosarcoma and intrahepatic cholangiocarcinoma. These …

Simple Summary In this review, the thorny issue of glioblastoma models is addressed, with a
focus on 3D in vitro models. In the first part of the manuscript, glioblastoma features and …

Glioblastoma (GBM) is the most common malignant primary tumor in the central nervous
system. Despite advances in neurosurgery, radiation therapy and chemotherapy, the …

Tumorigenesis is associated with the development of a highly variable pattern of cellular
diversity, consequence of genetic and epigenetic diversification, followed by clonal selection …

Neuroinflammation within the central nervous system involves multiple cell types that
coordinate their responses by secreting and responding to a plethora of inflammatory …

Malignant brain tumors are highly lethal and aggressive. Despite recent advances in the
current therapies, which include the combination of surgery and radio/chemotherapy, the …

Glioblastoma is the most malignant cancer in the brain and currently incurable. It is urgent to
identify effective targets for this lethal disease. Inhibition of such targets should suppress the …