In previous years, three‑dimensional (3D) cell culture technology has become a focus of
research in tumor cell biology, using a variety of methods and materials to mimic the in vivo …

Metastatic breast cancer cells disseminate to organs with a soft microenvironment. Whether
and how the mechanical properties of the local tissue influence their response to treatment …

Ductal carcinoma in situ (DCIS) represents pre-invasive breast carcinoma. In untreated
cases, 25–60% DCIS progress to invasive ductal carcinoma (IDC). The challenge lies in …

SOX11 is an embryonic mammary epithelial marker that is normally silenced prior to birth.
High SOX11 levels in breast tumours are significantly associated with distant metastasis and …

The MCF10 cell lines first described by Soule and colleagues in 1990 have been a great
resource for the breast cancer research community, facilitating research on the regulation of …

The mammary gland in adult women consists of biologically distinct cell types that differ in
their surface phenotypes. Isolation and molecular characterization of these subpopulations …

Despite decades of research and advancements in diagnostic and treatment modalities,
cancer remains a major global healthcare challenge. This is due in part to a lack of model …

Malignant bone tumors are aggressive neoplasms which arise from bone tissue or as a
result of metastasis. The most prevalent types of cancer, such as breast, prostate, and lung …

About one fourth of all newly identified cases of breast carcinoma are diagnoses of breast
ductal carcinoma in situ (DCIS). Since we cannot yet distinguish DCIS cases that would …

Here, we show that SOX11, an embryonic mammary marker that is normally silent in
postnatal breast cells, is expressed in many oestrogen receptor‐negative preinvasive ductal …