Contents Summary 49 I. Introduction 49 II. Physiological and structural characteristics of
plant Ca2+‐permeable ion channels 50 III. Ca2+ extrusion systems 61 IV. Concluding …

Lysosomes are acidic compartments filled with more than 60 different types of hydrolases.
They mediate the degradation of extracellular particles from endocytosis and of intracellular …

Ion selectivity is a defining feature of a given ion channel and is considered immutable. Here
we show that ion selectivity of the lysosomal ion channel TPC2, which is hotly debated …

The second messenger NAADP triggers Ca2+ release from endo‐lysosomes. Although two‐
pore channels (TPC s) have been proposed to be regulated by NAADP, recent studies have …

Abstract Calcium (Ca2+) and manganese (Mn2+) are essential elements for plants and have
similar ionic radii and binding coordination. They are assigned specific functions within …

Soil salinity is destroying arable land and is considered to be one of the major threats to
global food security in the 21st century. Therefore, the ability of naturally salt-tolerant …

Two-pore channels (TPCs) are evolutionarily important members of the voltage-gated ion
channel superfamily. TPCs localize to acidic Ca2+ stores within the endolysosomal system …

Nicotinic acid adenine dinucleotide phosphate (NAADP) is a potent Ca2+-mobilizing second
messenger which uniquely mobilizes Ca2+ from acidic endolysosomal organelles …

Luminal pH and the distinctive distribution of phosphatidylinositol phosphate (PIP) lipids are
central identifying features of organelles in all eukaryotic cells that are also critical for …

Since the discovery of the Ca 2+ mobilizing effects of the pyridine nucleotide metabolite,
nicotinic acid adenine dinucleotide phosphate (NAADP), this molecule has been …