(Single-stranded DNA) gaps in understanding BRCAness
A Schreuder, TJ Wendel, CGV Dorresteijn… - Trends in Genetics, 2024 - cell.com
The tumour-suppressive roles of BRCA1 and 2 have been attributed to three seemingly
distinct functions–homologous recombination, replication fork protection, and single …
distinct functions–homologous recombination, replication fork protection, and single …
How to sensitize glioblastomas to temozolomide chemotherapy: A gap-centered view
Temozolomide (TMZ) is a methylating agent used as the first-line drug in the chemotherapy
of glioblastomas. However, cancer cells eventually acquire resistance, necessitating the …
of glioblastomas. However, cancer cells eventually acquire resistance, necessitating the …
[HTML][HTML] Poly (ADP-Ribose) Polymerase Inhibitor Olaparib-Resistant BRCA1-Mutant Ovarian Cancer Cells Demonstrate Differential Sensitivity to PARP Inhibitor …
Poly (ADP-ribose) polymerase inhibitors (PARPis) show cytotoxicity in homologous
recombination deficiency (HRD) seen in BRCA-mutant ovarian cancer (OvCa). Despite …
recombination deficiency (HRD) seen in BRCA-mutant ovarian cancer (OvCa). Despite …
[HTML][HTML] Positioning Loss of PARP1 Activity as the Central Toxic Event in BRCA-Deficient Cancer
NJ MacGilvary, SB Cantor - DNA repair, 2024 - Elsevier
The mechanisms by which poly (ADP-ribose) polymerase 1 (PARP1) inhibitors (PARPi) s
inflict replication stress and/or DNA damage are potentially numerous. PARPi toxicity could …
inflict replication stress and/or DNA damage are potentially numerous. PARPi toxicity could …
[HTML][HTML] TRIM47 is a prognostic biomarker for gallbladder cancer and promotes tumor progression through regulating K63-linked ubiquitination of PARP1
M Xu, C Deng, Z Man, H Zhu - Translational Oncology, 2025 - Elsevier
Background Gallbladder cancer (GBC) is one of the most lethal malignancies worldwide
with an extremely poor prognosis. Previous studies have suggested that tripartite motif …
with an extremely poor prognosis. Previous studies have suggested that tripartite motif …
A perspective on tumor radiation resistance following high-LET radiation treatment
High-linear energy transfer (LET) radiation is a promising alternative to conventional low-
LET radiation for therapeutic gain against cancer owing to its ability to induce complex and …
LET radiation for therapeutic gain against cancer owing to its ability to induce complex and …
[HTML][HTML] Enriched G4 forming repeats in the human genome are associated with robust well-coordinated transcription and reduced cancer transcriptome variation
Non-B DNA G-quadruplex (G4) structures with guanine (G) runs of 2 to 4 repeats can trigger
opposing experimental transcriptional impacts. Here, we used bioinformatic algorithms to …
opposing experimental transcriptional impacts. Here, we used bioinformatic algorithms to …