Autophagy is a tightly regulated catabolic process wherein cells under stress sequester
cytosolic constituents like damaged proteins and organelles in double-membrane vesicles …

BECLIN1 is a well-established regulator of autophagy, a process essential for mammalian
survival. It functions in conjunction with other proteins to form Class III Phosphoinositide 3 …

Autophagy is a conserved intracellular degradation pathway essential for protein
homeostasis, survival and development. Defects in autophagic pathways have been …

The homeostatic link between oxidative stress and autophagy plays an important role in
cellular responses to a wide variety of physiological and pathological conditions. However …

Autophagy is an evolutionary conserved, degradative process from single-cell eukaryotes,
such as Saccharomyces cerevisiae, to higher mammals, such as humans. The regulation of …

Beclin 1 a yeast Atg6/VPS30 orthologue has a significant role in autophagy process
(Macroautophagy) and protein sorting. The function of beclin 1 depends on the interaction …

Eukaryotic cells use post-translational modifications to diversify and dynamically coordinate
the function and properties of protein networks within various cellular processes. For …

Recent clinical investigations indicate that anthracycline-based chemotherapies induce
early decline in heart mass in cancer patients. Heart mass decline may be caused by a …

Beclin 1 is a major regulator of autophagy, and it is a core component of the class III PI3K
complexes. Beclin 1 is a highly conserved protein and its function is regulated in a number …

Lipid signaling is defined as any biological signaling action in which a lipid messenger
binds to a protein target, converting its effects to specific cellular responses. In this complex …