Thrombolysis for acute ischaemic stroke: current status and future perspectives
Alteplase is currently the only approved thrombolytic agent for treatment of acute ischaemic
stroke, but interest is burgeoning in the development of new thrombolytic agents for systemic …
stroke, but interest is burgeoning in the development of new thrombolytic agents for systemic …
Ischemia-reperfusion injury: molecular mechanisms and therapeutic targets
Abstract Ischemia-reperfusion (I/R) injury paradoxically occurs during reperfusion following
ischemia, exacerbating the initial tissue damage. The limited understanding of the intricate …
ischemia, exacerbating the initial tissue damage. The limited understanding of the intricate …
Thrombectomy alone versus intravenous alteplase plus thrombectomy in patients with stroke: an open-label, blinded-outcome, randomised non-inferiority trial
U Fischer, J Kaesmacher, D Strbian, O Eker… - The Lancet, 2022 - thelancet.com
Background Whether thrombectomy alone is equally as effective as intravenous alteplase
plus thrombectomy remains controversial. We aimed to determine whether thrombectomy …
plus thrombectomy remains controversial. We aimed to determine whether thrombectomy …
Effect of mechanical thrombectomy without vs with intravenous thrombolysis on functional outcome among patients with acute ischemic stroke: the SKIP randomized …
K Suzuki, Y Matsumaru, M Takeuchi, M Morimoto… - Jama, 2021 - jamanetwork.com
Importance Whether intravenous thrombolysis is needed in combination with mechanical
thrombectomy in patients with acute large vessel occlusion stroke is unclear. Objective To …
thrombectomy in patients with acute large vessel occlusion stroke is unclear. Objective To …
Endovascular thrombectomy with or without intravenous alteplase in acute stroke
P Yang, Y Zhang, L Zhang, Y Zhang… - … England Journal of …, 2020 - Mass Medical Soc
Background In acute ischemic stroke, there is uncertainty regarding the benefit and risk of
administering intravenous alteplase before endovascular thrombectomy. Methods We …
administering intravenous alteplase before endovascular thrombectomy. Methods We …
European Stroke Organisation (ESO) expedited recommendation on tenecteplase for acute ischaemic stroke
S Alamowitch, G Turc, L Palaiodimou… - European Stroke …, 2023 - journals.sagepub.com
Within the last year, four randomised-controlled clinical trials (RCTs) have been published
comparing intravenous thrombolysis (IVT) with tenecteplase and alteplase in acute …
comparing intravenous thrombolysis (IVT) with tenecteplase and alteplase in acute …
Value of intravenous thrombolysis in endovascular treatment for large-vessel anterior circulation stroke: individual participant data meta-analysis of six randomised …
CB Majoie, F Cavalcante, J Gralla, P Yang… - The lancet, 2023 - thelancet.com
Background Intravenous thrombolysis is recommended before endovascular treatment, but
its value has been questioned in patients who are admitted directly to centres capable of …
its value has been questioned in patients who are admitted directly to centres capable of …
European Stroke Organisation (ESO)–European Society for Minimally Invasive Neurological Therapy (ESMINT) expedited recommendation on indication for …
Six randomized controlled clinical trials have assessed whether mechanical thrombectomy
(MT) alone is non-inferior to intravenous thrombolysis (IVT) plus MT within 4.5 hours of …
(MT) alone is non-inferior to intravenous thrombolysis (IVT) plus MT within 4.5 hours of …
European Stroke Organisation–European Society for Minimally Invasive Neurological Therapy expedited recommendation on indication for intravenous thrombolysis …
Six randomized controlled clinical trials have assessed whether mechanical thrombectomy
(MT) alone is non-inferior to intravenous thrombolysis (IVT) plus MT within 4.5 hours of …
(MT) alone is non-inferior to intravenous thrombolysis (IVT) plus MT within 4.5 hours of …
Bridging thrombolysis achieved better outcomes than direct thrombectomy after large vessel occlusion: an updated meta-analysis
The utility and necessity of pretreatment with intravenous thrombolysis (IVT) before
mechanical thrombectomy (MT) remains an issue of strong debate. This study aims to …
mechanical thrombectomy (MT) remains an issue of strong debate. This study aims to …