Molecular biomarkers in idiopathic pulmonary fibrosis: state of the art and future directions

A Stainer, P Faverio, S Busnelli, M Catalano… - International Journal of …, 2021 - mdpi.com
Idiopathic pulmonary fibrosis (IPF), the most lethal form of interstitial pneumonia of unknown
cause, is associated with a specific radiological and histopathological pattern (the so-called …

The role of Nrf2 in pulmonary fibrosis: molecular mechanisms and treatment approaches

Y Wang, J Wei, H Deng, L Zheng, H Yang, X Lv - Antioxidants, 2022 - mdpi.com
Pulmonary fibrosis is a chronic, progressive, incurable interstitial lung disease with high
mortality after diagnosis and remains a global public health problem. Despite advances and …

Pharmacologic differentiation of inflammation and fibrosis in the rat bleomycin model

NI Chaudhary, A Schnapp, JE Park - American journal of respiratory …, 2006 - atsjournals.org
Rationale: The model most often used to study the pathogenesis of pulmonary fibroses is the
bleomycin (BLM)-induced lung fibrosis model. Several treatments have been efficacious in …

Cryptotanshinone protects against pulmonary fibrosis through inhibiting Smad and STAT3 signaling pathways

Y Zhang, W Lu, X Zhang, J Lu, S Xu, S Chen… - Pharmacological …, 2019 - Elsevier
Cryptotanshinone (CTS), a lipophilic compound extracted from root of Salvia miltiorrhiza
(Danshen), has demonstrated multiple pharmacological activities, including anti …

Fra-2–expressing macrophages promote lung fibrosis

AC Ucero, L Bakiri, B Roediger… - The Journal of …, 2019 - Am Soc Clin Investig
Idiopathic pulmonary fibrosis (IPF) is a deadly disease with limited therapies. Tissue fibrosis
is associated with type 2 immune response, although the causal contribution of immune …

[HTML][HTML] Fluvoxamine alleviates bleomycin-induced lung fibrosis via regulating the cGAS-STING pathway

X Xie, X Wu, D Zhao, Y Liu, Q Du, Y Li, Y Xu, Y Li… - Pharmacological …, 2023 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a fatal disease with high mortality and limited effective
therapy. Herein, we reported that fluvoxamine, a selective serotonin reuptake inhibitor …

A systematic review of the role of dysfunctional wound healing in the pathogenesis and treatment of idiopathic pulmonary fibrosis

A Betensley, R Sharif, D Karamichos - Journal of clinical medicine, 2016 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disorder
showcasing an interaction between genetic predisposition and environmental risks. This …

Heat shock protein 70 protects against bleomycin-induced pulmonary fibrosis in mice

KI Tanaka, Y Tanaka, T Namba, A Azuma… - Biochemical …, 2010 - Elsevier
Idiopathic pulmonary fibrosis (IPF) involves infiltration of leucocytes, pulmonary injury,
fibrosis and resulting pulmonary dysfunction. Myofibroblasts and transforming growth factor …

[HTML][HTML] The NRF2-LOC344887 signaling axis suppresses pulmonary fibrosis

P Liu, G Luo, M Dodson, CJ Schmidlin, Y Wei… - Redox Biology, 2021 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a progressive and irreversible disease characterized
by an increase in differentiation of fibroblasts to myofibroblasts and excessive accumulation …

Inula japonica ameliorated bleomycin-induced pulmonary fibrosis via inhibiting soluble epoxide hydrolase

WY Zhao, ZL Luan, TT Liu, WH Ming, XK Huo… - Bioorganic …, 2020 - Elsevier
Pulmonary fibrosis is a progressive, irreversible, and fatal fibrotic lung disease with a high
mortality and morbidity, and commonly nonresponsive to conventional therapy. Inula …