Payload diversification: a key step in the development of antibody–drug conjugates

L Conilh, L Sadilkova, W Viricel, C Dumontet - Journal of Hematology & …, 2023 - Springer
Antibody–drug conjugates (ADCs) is a fast moving class of targeted biotherapeutics that
currently combines the selectivity of monoclonal antibodies with the potency of a payload …

Smart chemistry in polymeric nanomedicine

R Tong, L Tang, L Ma, C Tu, R Baumgartner… - Chemical Society …, 2014 - pubs.rsc.org
This review provides an overview of smart chemistry developed and utilized in the last 5–10
years in polymer-based drug delivery nanomedicine. Smart chemistry not only facilitates the …

Lipid polymer hybrid as emerging tool in nanocarriers for oral drug delivery

SS Hallan, P Kaur, V Kaur, N Mishra… - Artificial cells …, 2016 - Taylor & Francis
The oral route for drug delivery is a widely accepted route. For that reason, many
researchers are currently working to develop efficient oral drug delivery systems. Use of …

Daunorubicin-TiO2 nanocomposites as a “smart” pH-responsive drug delivery system

H Zhang, C Wang, B Chen, X Wang - International journal of …, 2012 - Taylor & Francis
Daunorubicin (DNR) has a broad spectrum of anticancer activity, but is limited in clinical
application due to its serious side effects. The aim of this study was to explore a novel …

Magnetic field activated lipid–polymer hybrid nanoparticles for stimuli-responsive drug release

SD Kong, M Sartor, CMJ Hu, W Zhang, L Zhang, S Jin - Acta biomaterialia, 2013 - Elsevier
Stimuli-responsive nanoparticles (SRNPs) offer the potential of enhancing the therapeutic
efficacy and minimizing the side-effects of chemotherapeutics by controllably releasing the …

Recent advances on the development of pharmacotherapeutic agents on the basis of human serum albumin

F Liu, J Mu, B Xing - Current pharmaceutical design, 2015 - ingentaconnect.com
Human serum albumin (HSA), a major transport protein component in blood plasma, has
been reported recently to play many important roles in pharmacotherapeutics development …

A pH-responsive crosslinker platform for antibody-drug conjugate (ADC) targeting delivery

F Migliorini, E Cini, E Dreassi, F Finetti… - Chemical …, 2022 - pubs.rsc.org
We report a new 1–6 self-immolative, traceless crosslinker derived from the natural product
gallic acid. The linker acts through a pH-dependent mechanism for drug release. This 5 …

Endogenous stimuli-responsive linkers in nanoliposomal systems for cancer drug targeting

MF Maleki, A Jafari, E Mirhadi, A Askarizadeh… - International journal of …, 2019 - Elsevier
There are various drug delivery systems (DDSs) among which nanoliposomal formulations
are among the most prominent. Despite the superiority of nanoliposomal DDSs compared to …

Nanoparticle-based drug delivery systems targeting tumor microenvironment for cancer immunotherapy resistance: current advances and applications

P Wu, J Han, Y Gong, C Liu, H Yu, N Xie - Pharmaceutics, 2022 - mdpi.com
Cancer immunotherapy has shown impressive anti-tumor activity in patients with advanced
and early-stage malignant tumors, thus improving long-term survival. However, current …

Water‐Soluble Triazabutadienes that Release Diazonium Species upon Protonation under Physiologically Relevant Conditions

FW Kimani, JC Jewett - Angewandte Chemie, 2015 - Wiley Online Library
Triazabutadienes are an understudied structural motif that have remarkable reactivity once
rendered water‐soluble. It is shown that these molecules readily release diazonium species …