Payload diversification: a key step in the development of antibody–drug conjugates
L Conilh, L Sadilkova, W Viricel, C Dumontet - Journal of Hematology & …, 2023 - Springer
Antibody–drug conjugates (ADCs) is a fast moving class of targeted biotherapeutics that
currently combines the selectivity of monoclonal antibodies with the potency of a payload …
currently combines the selectivity of monoclonal antibodies with the potency of a payload …
Smart chemistry in polymeric nanomedicine
This review provides an overview of smart chemistry developed and utilized in the last 5–10
years in polymer-based drug delivery nanomedicine. Smart chemistry not only facilitates the …
years in polymer-based drug delivery nanomedicine. Smart chemistry not only facilitates the …
Lipid polymer hybrid as emerging tool in nanocarriers for oral drug delivery
The oral route for drug delivery is a widely accepted route. For that reason, many
researchers are currently working to develop efficient oral drug delivery systems. Use of …
researchers are currently working to develop efficient oral drug delivery systems. Use of …
Daunorubicin-TiO2 nanocomposites as a “smart” pH-responsive drug delivery system
H Zhang, C Wang, B Chen, X Wang - International journal of …, 2012 - Taylor & Francis
Daunorubicin (DNR) has a broad spectrum of anticancer activity, but is limited in clinical
application due to its serious side effects. The aim of this study was to explore a novel …
application due to its serious side effects. The aim of this study was to explore a novel …
Magnetic field activated lipid–polymer hybrid nanoparticles for stimuli-responsive drug release
Stimuli-responsive nanoparticles (SRNPs) offer the potential of enhancing the therapeutic
efficacy and minimizing the side-effects of chemotherapeutics by controllably releasing the …
efficacy and minimizing the side-effects of chemotherapeutics by controllably releasing the …
Recent advances on the development of pharmacotherapeutic agents on the basis of human serum albumin
Human serum albumin (HSA), a major transport protein component in blood plasma, has
been reported recently to play many important roles in pharmacotherapeutics development …
been reported recently to play many important roles in pharmacotherapeutics development …
A pH-responsive crosslinker platform for antibody-drug conjugate (ADC) targeting delivery
F Migliorini, E Cini, E Dreassi, F Finetti… - Chemical …, 2022 - pubs.rsc.org
We report a new 1–6 self-immolative, traceless crosslinker derived from the natural product
gallic acid. The linker acts through a pH-dependent mechanism for drug release. This 5 …
gallic acid. The linker acts through a pH-dependent mechanism for drug release. This 5 …
Endogenous stimuli-responsive linkers in nanoliposomal systems for cancer drug targeting
There are various drug delivery systems (DDSs) among which nanoliposomal formulations
are among the most prominent. Despite the superiority of nanoliposomal DDSs compared to …
are among the most prominent. Despite the superiority of nanoliposomal DDSs compared to …
Nanoparticle-based drug delivery systems targeting tumor microenvironment for cancer immunotherapy resistance: current advances and applications
P Wu, J Han, Y Gong, C Liu, H Yu, N Xie - Pharmaceutics, 2022 - mdpi.com
Cancer immunotherapy has shown impressive anti-tumor activity in patients with advanced
and early-stage malignant tumors, thus improving long-term survival. However, current …
and early-stage malignant tumors, thus improving long-term survival. However, current …
Water‐Soluble Triazabutadienes that Release Diazonium Species upon Protonation under Physiologically Relevant Conditions
Triazabutadienes are an understudied structural motif that have remarkable reactivity once
rendered water‐soluble. It is shown that these molecules readily release diazonium species …
rendered water‐soluble. It is shown that these molecules readily release diazonium species …