Fused xanthone derivatives as antiproliferative agents
Xanthones have been isolated from several natural sources, mainly belonging in Guttiferae
and Gentianaceae families as secondary plant metabolites and many of them are endowed …
and Gentianaceae families as secondary plant metabolites and many of them are endowed …
Antiproliferative activity of Greek propolis
The butanolic extract and the isolated chemical constituents, mainly diterpenes and
flavonoids, from Greek propolis have been tested for their cytostatic activities against human …
flavonoids, from Greek propolis have been tested for their cytostatic activities against human …
Routes to xanthones: an update on the synthetic approaches
C Miguel Goncalves Azevedo… - Current Organic …, 2012 - ingentaconnect.com
Xanthones belong to a class of O-heterocycles which are known for their great variety of
biological/pharmacological activities. The xanthone scaffold can be considered as a …
biological/pharmacological activities. The xanthone scaffold can be considered as a …
Design, synthesis, structure-activity relationships and X-ray structural studies of novel 1-oxopyrimido [4, 5-c] quinoline-2-acetic acid derivatives as selective and potent …
I Crespo, J Gimenez-Dejoz, S Porte… - European Journal of …, 2018 - Elsevier
Human aldose reductase (AKR1B1, AR) is a key enzyme of the polyol pathway, catalyzing
the reduction of glucose to sorbitol at high glucose concentrations, as those found in diabetic …
the reduction of glucose to sorbitol at high glucose concentrations, as those found in diabetic …
Synthesis and free radical scavenging activity of some new spiropyranocoumarins
A series of novel spiro-substituted 4-hydroxypyranocoumarins and their corresponding
dihydropyrano cis-diols has been synthesized. Among them the …
dihydropyrano cis-diols has been synthesized. Among them the …
Tetrahydroxanthones by sequential Pd-catalyzed C− O and C− C bond construction and use in the identification of the “antiausterity” pharmacophore of the kigamicins
PA Turner, EM Griffin, JL Whatmore, M Shipman - Organic Letters, 2011 - ACS Publications
Readily available C-acylated cycloalkanones undergo efficient Pd catalyzed ring
closure/cross-coupling providing 7-substituted tetrahydroxanthones in a single operation …
closure/cross-coupling providing 7-substituted tetrahydroxanthones in a single operation …
Xanthone synthetic derivatives with high anticandidal activity and positive mycostatic selectivity index values
With the current massive increases in drug-resistant microbial infection as well as the
significant role of fungal infections in the death toll of COVID-19, discovering new antifungals …
significant role of fungal infections in the death toll of COVID-19, discovering new antifungals …
Indazoles: Synthesis and Bond-Forming Heterocyclization
Indazoles (azaindoles) are heterocyclic compounds structurally related to indoles and can
be viewed as indole isosteres. The indazole moiety is a 10-π electron aromatic heterocyclic …
be viewed as indole isosteres. The indazole moiety is a 10-π electron aromatic heterocyclic …
The discovery of new cytotoxic pyrazolopyridine derivatives
Abstract A number of new 3, 7-disubstituted pyrazolo [3, 4-c] pyridines have been designed
and synthesized from suitable 2-aminopyridines. The antiproliferative activity of the …
and synthesized from suitable 2-aminopyridines. The antiproliferative activity of the …
Bioactive xanthones with effect on P-glycoprotein and prediction of intestinal absorption
E Sousa, A Palmeira, AS Cordeiro, B Sarmento… - Medicinal Chemistry …, 2013 - Springer
Our research group has been focusing in the discovery of potential antitumor small
molecules based on the xanthone scaffold. However, a serious obstacle in the field of …
molecules based on the xanthone scaffold. However, a serious obstacle in the field of …