With the advent of rapid genotyping and next‐generation sequencing technologies, genome‐
wide association study (GWAS) has become a routine strategy for decoding genotype …

Genome-wide association studies (GWAS) have revealed thousands of genetic loci that
underpin the complex biology of many human traits. However, the strength of GWAS–the …

Given the challenges of population growth and climate change, there is an urgent need to
expedite the development of high‐yielding stress‐tolerant crop cultivars. While traditional …

The effect of a mutation on the organism often depends on what other mutations are already
present in its genome. Geneticists refer to such mutational interactions as epistasis. Pairwise …

Over the last decade, genome-wide association studies (GWAS) have discovered thousands
of genetic variants underlying complex human diseases and agriculturally important traits …

Genome-wide association study is especially challenging in detecting high-order disease-
causing models due to model diversity, possible low or even no marginal effect of the model …

Background Major challenges in large scale genetic association studies include not only the
identification of causative single nucleotide polymorphisms (SNPs), but also accounting for …

Advances in high-throughput sequencing technologies have made it possible to access
millions of measurements from thousands of people. Single nucleotide polymorphisms …

Abstract Background Genome-wide Association Studies (GWAS) have contributed to
unraveling associations between genetic variants in the human genome and complex traits …

Background Detection of gene-gene interaction (GGI) is a key challenge towards solving the
problem of missing heritability in genetics. The multifactor dimensionality reduction (MDR) …