Intersections of fibrodysplasia ossificans progressiva and traumatic heterotopic ossification

C Juan, AC Bancroft, JH Choi, JH Nunez, CA Pagani… - Biomolecules, 2024 - mdpi.com
Heterotopic ossification (HO) is a debilitating pathology where ectopic bone develops in
areas of soft tissue. HO can develop as a consequence of traumatic insult or as a result of …

Biomaterials in heterotopic ossification: Prophylaxis and promotion

X Lou, D Huang, G Li, L Bai, J Su, H Yue - Chemical Engineering Journal, 2024 - Elsevier
Heterotopic ossification (HO) is an abnormal bone formation within non-skeletal tissues,
impairing daily functionality and significantly diminishing patient quality of life. This condition …

Identification of candidate genes and chemicals associated with osteonecrosis of femoral head by multiomics studies and chemical-gene interaction analysis

X Lu, X Wang, P Wang, Y Zhu, J Liu, G Liu… - Frontiers in …, 2024 - frontiersin.org
Objectives In-depth understanding of osteonecrosis of femoral head (ONFH) has revealed
that degeneration of the hip cartilage plays a crucial role in ONFH progression. However, the …

Cellular and Molecular Mechanisms of Heterotopic Ossification in Fibrodysplasia Ossificans Progressiva

L Mejias Rivera, EM Shore, F Mourkioti - Biomedicines, 2024 - mdpi.com
Fibrodysplasia ossificans progressiva (FOP) is a debilitating genetic disorder characterized
by recurrent episodes of heterotopic ossification (HO) formation in muscles, tendons, and …

Animal models of tendon calcification: Past, present, and future

R Li, C Lai, H Luo, Y Lan, X Duan, D Bao… - Animal Models and …, 2024 - Wiley Online Library
Tendon calcification is a common clinical condition that frequently occurs as a complication
after tendon injury and surgery, or as an expression of fibrodysplasia ossificans progressiva …

Single‐cell RNA sequencing reveals the CRTAC1+ population actively contributes to the pathogenesis of spinal ligament degeneration by SPP1+ macrophage

Y Tang, D Zhuo, Y Yu, W Pu, Y Ma, Y Zhang, Y Huang… - Aging Cell - Wiley Online Library
Degenerative spinal stenosis is a chronic disease that affects the spinal ligaments and
associated bones, resulting in back pain and disorders of the limbs among the elderly …

Tendon Heterotopic Ossification Induced by Activation of Hedgehog Signaling

J Robbins - 2024 - search.proquest.com
The tendon enthesis is the mineralized graded structure, which connects tendon to bone.
Upon injury, this graded structure is not regenerated through healing, resulting in a …