Alzheimer's disease (AD) is the most common cause of dementia worldwide, and its
prevalence is rapidly increasing due to extended lifespans. Among the increasing number of …

ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …

Much evidence shows that physical exercise (PE) is a strong gene modulator that induces
structural and functional changes in the brain, determining enormous benefit on both …

We discuss the factors that encouraged us to examine the question of whether exercise
training has a positive influence on cognitive health of older adults in 2003. At that time there …

Chronic diseases are major killers in the modern era. Physical inactivity is a primary cause
of most chronic diseases. The initial third of the article considers: activity and prevention …

Significant progress has been made in understanding the neurobiological mechanisms
through which exercise protects and restores the brain. In this feature review, we integrate …

Scientific evidence based on neuroimaging approaches over the last decade has
demonstrated the efficacy of physical activity improving cognitive health across the human …

Evidence is accumulating that exercise has profound benefits for brain function. Physical
activity improves learning and memory in humans and animals. Moreover, an active lifestyle …

APOE-ε4 is best known as a risk factor for Alzheimer's disease (AD). Consequently, there is
considerable research interest in understanding whether APOE-ε4 influences cognition in …

Alzheimer's disease (AD) afflicts more than 5.4 million Americans and ranks as the most
common type of dementia (Thies and Bleiler, 2011), yet effective pharmacological …