Emerging roles of Sirtuin 2 in cardiovascular diseases

A Taneja, V Ravi, JY Hong, H Lin… - The FASEB …, 2021 - Wiley Online Library
Sirtuins are a family of NAD+‐dependent deacetylases implicated in a wide variety of age‐
associated pathologies, including cardiovascular disorders. Among the seven mammalian …

Therapeutic activities of the main bioactive compounds via modulating sirtuins: A review

H Poormazaheri, N Zaman Samghabadi… - Micro Nano Bio …, 2024 - mnba-journal.com
Multiple cellular processes such as inflammation and apoptosis have been regulated by
sirtuin (SIRT) proteins as highly conserved signaling proteins in eukaryotes, prokaryotes …

New sirtuin modulators: their uncovering, pharmacophore, and implications in drug discovery

PT Chen, KY Yeong - Medicinal Chemistry Research, 2024 - Springer
Sirtuins are a group of enzymes known as class III histone deacetylases that catalyze the
deacetylation reaction and are presented across various species. In humans, they exhibit …

Age-related pathologies and life span

G Cocco, S Pandolfi - OBM Geriatrics, 2023 - lidsen.com
Both from a healthcare and a socioeconomic perspective, research on senescence is
increasingly essential. Indeed, in industrialized countries, the increased human longevity …