[HTML][HTML] Regulation and function of DNA methylation in plants and animals
DNA methylation is an important epigenetic mark involved in diverse biological processes.
In plants, DNA methylation can be established through the RNA-directed DNA methylation …
In plants, DNA methylation can be established through the RNA-directed DNA methylation …
[HTML][HTML] Evidence of sex differences in cellular senescence
M Ng, LN Hazrati - Neurobiology of Aging, 2022 - Elsevier
Biological sex is a factor in many conditions, including aging, neurodegenerative disease,
cancer, and more. For each of these, men and women display distinct differences in disease …
cancer, and more. For each of these, men and women display distinct differences in disease …
The inactive X chromosome adopts a unique three-dimensional conformation that is dependent on Xist RNA
Three-dimensional topology of DNA in the cell nucleus provides a level of transcription
regulation beyond the sequence of the linear DNA. To study the relationship between the …
regulation beyond the sequence of the linear DNA. To study the relationship between the …
[HTML][HTML] The central role of RNA in human development and cognition
JS Mattick - FEBS letters, 2011 - Elsevier
It appears that the genetic programming of humans and other complex organisms has been
misunderstood for the past 50 years, due to the assumption that most genetic information is …
misunderstood for the past 50 years, due to the assumption that most genetic information is …
Decoding the function of nuclear long non-coding RNAs
LL Chen, GG Carmichael - Current opinion in cell biology, 2010 - Elsevier
Long non-coding RNAs (lncRNAs) are mRNA-like, non-protein-coding RNAs that are
pervasively transcribed throughout eukaryotic genomes. Rather than silently accumulating …
pervasively transcribed throughout eukaryotic genomes. Rather than silently accumulating …
[HTML][HTML] Epigenetic transitions in germ cell development and meiosis
SK Kota, R Feil - Developmental cell, 2010 - cell.com
Germ cell development is controlled by unique gene expression programs and involves
epigenetic reprogramming of histone modifications and DNA methylation. The central event …
epigenetic reprogramming of histone modifications and DNA methylation. The central event …
Long non-coding RNAs and chromatin modifiers: their place in the epigenetic code
FP Marchese, M Huarte - Epigenetics, 2014 - Taylor & Francis
The emergence of long non-coding RNAs (lncRNAs) has shaken up our conception of gene
expression regulation, as lncRNAs take prominent positions as components of cellular …
expression regulation, as lncRNAs take prominent positions as components of cellular …
[HTML][HTML] A pathophysiological view of the long non-coding RNA world
F Di Gesualdo, S Capaccioli, M Lulli - Oncotarget, 2014 - ncbi.nlm.nih.gov
Because cells are constantly exposed to micro-environmental changes, they require the
ability to adapt to maintain a dynamic equilibrium. Proteins are considered critical for the …
ability to adapt to maintain a dynamic equilibrium. Proteins are considered critical for the …
[HTML][HTML] Smchd1-dependent and-independent pathways determine developmental dynamics of CpG island methylation on the inactive X chromosome
AV Gendrel, A Apedaile, H Coker, A Termanis… - Developmental cell, 2012 - cell.com
X chromosome inactivation involves multiple levels of chromatin modification, established
progressively and in a stepwise manner during early development. The chromosomal …
progressively and in a stepwise manner during early development. The chromosomal …
[HTML][HTML] The chromatin signaling pathway: diverse mechanisms of recruitment of histone-modifying enzymes and varied biological outcomes
E Smith, A Shilatifard - Molecular cell, 2010 - cell.com
Posttranslational modifications of histones are coupled in the regulation of the cellular
processes involving chromatin, such as transcription, replication, repair, and genome …
processes involving chromatin, such as transcription, replication, repair, and genome …