An increasing number of epilepsies are being attributed to variants in genes with epigenetic
functions. The products of these genes include factors that regulate the structure and …

Aim There is insufficient evidence regarding the efficacy and safety of stem cell therapy for
autism spectrum disorders. We performed the first meta-analysis of stem cell therapy for …

The mammalian neocortex is a highly organized six-layered structure with four major cortical
neuron subtypes: corticothalamic projection neurons (CThPNs), subcerebral projection …

Cataloging the diverse cellular architecture of the primate brain is crucial for understanding
cognition, behavior, and disease in humans. Here, we generated a brain-wide single-cell …

Background FOXG1-related encephalopathy, also known as FOXG1 syndrome or FOXG1-
related disorder, affects most aspects of development and causes microcephaly and brain …

There is a growing evidence that methylation at the N 6 position of adenine (6-mA), whose
modulation occurs primarily during development, would be a reliable epigenetic marker in …

Cortical GABAergic interneurons are critical components of neural networks. They provide
local and long-range inhibition and help coordinate network activities involved in various …

GABAergic inhibitory interneurons, originating from the embryonic ventral forebrain
territories, traverse a convoluted migratory path to reach the neocortex. These interneuron …

Forkhead box G1 (FOXG1) has important functions in neuronal differentiation and balances
excitatory/inhibitory network activity. Thus far, molecular processes underlying FOXG1 …

FOXG1 syndrome (FS, aka a congenital variant of Rett syndrome) is a recently defined rare
and devastating neurodevelopmental disorder characterized by various symptoms …