The brain processes information by transmitting signals at synapses, which connect neurons
into vast networks of communicating cells. In these networks, synapses not only transmit …

There is strong evidence that genetic factors make substantial contributions to the etiology of
autism, schizophrenia and bipolar disorders, with heritability estimates being at least 80 …

Research has implicated mutations in the gene for neurexin‐1 (NRXN1) in a variety of
conditions including autism, schizophrenia, and nicotine dependence. To our knowledge …

The neurexin family of cell adhesion proteins consists of three members in vertebrates and
has homologs in several invertebrate species. In mammals, each neurexin gene encodes an …

Background Copy number variants have emerged as an important genomic cause of
common, complex neurodevelopmental disorders. These usually change copy number of …

The corticostriatal pathway that carries sensory, motor, and limbic information to the striatum
plays a critical role in motor control, action selection, and reward. Dysfunction of this …

Neurodevelopmental disorders (NDDs) are a group of diseases whose symptoms arise
during childhood or adolescence and that impact several higher cognitive functions such as …

Voltage‐gated calcium (CaV) channels and their regulation by proteins at the synaptic cleft
play a critical role in neurotransmission. These interactions fine‐tune the synaptic response …

The authors report a patient with mild mental retardation, autistic features, multiple vertebral
malformations, and an unusual facial appearance who carries a de novo submicroscopic …

Action potential-evoked neurotransmitter release is impaired in knock-out neurons lacking
synaptic cell-adhesion molecules α-neurexins (αNrxns), the extracellularly longer variants of …