Lipids are essential metabolites, which function as energy sources, structural components
and signalling mediators. Most cells are able to convert carbohydrates into fatty acids, which …

In order to ensure normal body function, the human body is dependent on a tight control of
its blood glucose levels. This is accomplished by a highly sophisticated network of various …

Hepatic steatosis is present in insulin-resistant obese rodents and is concomitant with active
lipogenesis. Hepatic lipogenesis depends on the insulin-induced activation of the …

Purpose of review Insulin resistance (IR) is recognized to play an important role in the
pathogenesis of dyslipidemia. This review summarizes the complex interplay between IR …

Our understanding of metabolism is undergoing a dramatic shift. Indeed, the efforts made
towards elucidating the mechanisms controlling the major regulatory pathways are now …

Insulin resistance is a hallmark of diabetes and an unmet clinical need. Insulin inhibits
hepatic glucose production and promotes lipogenesis by suppressing FOXO1-dependent …

Forkhead proteins, and FoxO1 in particular, play a significant role in regulating whole body
energy metabolism. Glucose homeostasis is achieved by adjusting endogenous glucose …

The glucokinase (GCK) gene was one of the first candidate genes to be identified as a
human “diabetes gene". Subsequently, important advances were made in understanding the …

Growing epidemiological evidence suggests that nonalcoholic fatty liver disease (NAFLD) is
an early predictor of and determinant for the development of type 2 diabetes and other …

In mammals, the regulation of hepatic metabolism plays a key role in whole body energy
balance, since the liver is the major site of carbohydrate metabolism (glycolysis and …