Comparison of microgravity analogs to spaceflight in studies of plant growth and development

JZ Kiss, C Wolverton, SE Wyatt… - Frontiers in plant …, 2019 - frontiersin.org
Life on Earth has evolved under the influence of gravity. This force has played an important
role in shaping development and morphology from the molecular level to the whole …

Factors implicating the validity and interpretation of mechanobiology studies in simulated microgravity environments

C Poon - Engineering Reports, 2020 - Wiley Online Library
Simulated microgravity (s‐μg) devices provide unique conditions for elucidating the effects
of gravitational unloading on biological processes and are increasingly being applied for …

Novel, Moon and Mars, partial gravity simulation paradigms and their effects on the balance between cell growth and cell proliferation during early plant development

A Manzano, R Herranz, LA den Toom, S Te Slaa… - npj …, 2018 - nature.com
Abstract Clinostats and Random Positioning Machine (RPM) are used to simulate
microgravity, but, for space exploration, we need to know the response of living systems to …

Dexamethasone selectively inhibits detachment of metastatic thyroid cancer cells during random positioning

D Melnik, JL Cortés-Sánchez, V Sandt, S Kahlert… - Cancers, 2023 - mdpi.com
Simple Summary Metastasis is the most dangerous feature of advanced cancers. In vitro
models of this process could help us to study and understand mechanisms that are not …

Gene-environmental influence of space and microgravity on red blood cells with sickle cell disease

NE Igbineweka, JJWA van Loon - NPJ Genomic Medicine, 2024 - nature.com
A fundamental question in human biology and for hematological disease is how do complex
gene-environment interactions lead to individual disease outcome? This is no less the case …

Simulated microgravity inhibits the proliferation of chang liver cells by attenuation of the major cell cycle regulators and cytoskeletal proteins

CNQ Ho, MT Tran, CC Doan, SN Hoang… - International Journal of …, 2021 - mdpi.com
Simulated microgravity (SMG) induced the changes in cell proliferation and cytoskeleton
organization, which plays an important factor in various cellular processes. The inhibition in …

[HTML][HTML] Differential transcriptional profile through cell cycle progression in Arabidopsis cultures under simulated microgravity

KY Kamal, JJWA van Loon, FJ Medina, R Herranz - Genomics, 2019 - Elsevier
Plant cell proliferation is affected by microgravity during spaceflight, but involved molecular
mechanisms, key for space agronomy goals, remain unclear. To investigate transcriptomic …

Fluid and Bubble Flow Detach Adherent Cancer Cells to Form Spheroids on a Random Positioning Machine

JL Cortés-Sánchez, D Melnik, V Sandt, S Kahlert… - Cells, 2023 - mdpi.com
In preparing space and microgravity experiments, the utilization of ground-based facilities is
common for initial experiments and feasibility studies. One approach to simulating …

Morphological Changes of 3T3 Cells under Simulated Microgravity

MT Tran, CNQ Ho, SN Hoang, CC Doan, MT Nguyen… - Cells, 2024 - mdpi.com
Background: Cells are sensitive to changes in gravity, especially the cytoskeletal structures
that determine cell morphology. The aim of this study was to assess the effects of simulated …

Omics Studies of Tumor Cells under Microgravity Conditions

J Graf, H Schulz, M Wehland, TJ Corydon… - International Journal of …, 2024 - mdpi.com
Cancer is defined as a group of diseases characterized by abnormal cell growth, expansion,
and progression with metastasis. Various signaling pathways are involved in its …