Novel Biomarkers and Molecular Targets in ALL
H De Sa, J Leonard - Current Hematologic Malignancy Reports, 2024 - Springer
Abstract Purpose of Review Acute lymphoblastic leukemia (ALL) is a widely heterogeneous
disease in terms of genomic alterations, treatment options, and prognosis. While ALL is …
disease in terms of genomic alterations, treatment options, and prognosis. While ALL is …
[HTML][HTML] NRXN1 as a novel potential target of antibody-drug conjugates for small cell lung cancer
T Yotsumoto, K Maemura, K Watanabe, Y Amano… - Oncotarget, 2020 - ncbi.nlm.nih.gov
Small cell lung cancer (SCLC) is a high-grade malignancy, and treatment strategies have
not changed for decades. In this study, we searched for novel targets for antibody-drug …
not changed for decades. In this study, we searched for novel targets for antibody-drug …
Discovery of small-molecule inhibitors of the PTK7/β-catenin interaction targeting the Wnt signaling pathway in colorectal cancer
L Ganier, S Betzi, C Derviaux, P Roche… - ACS Chemical …, 2022 - ACS Publications
Colorectal cancer (CRC), the second cause of death due to cancer worldwide, is a major
public health issue. The discovery of new therapeutic targets is thus essential …
public health issue. The discovery of new therapeutic targets is thus essential …
Next generation payloads for ADCs
LN Tumey - Innovations for Next-Generation Antibody-Drug …, 2018 - Springer
The clinical success of gemtuzumab ozogamicin, brentuximab vedotin and ado-trastuzumab
emtansine has spurred significant investment into new ADC payloads that may expand the …
emtansine has spurred significant investment into new ADC payloads that may expand the …
Autocrine signaling by receptor tyrosine kinases in urothelial carcinoma of the bladder
YH Lee, MM Lee, DM De Silva, A Roy, CE Wright… - Plos one, 2021 - journals.plos.org
Comprehensive characterizations of bladder cancer (BCa) have established molecular
phenotype classes with distinct alterations and survival trends. Extending these studies …
phenotype classes with distinct alterations and survival trends. Extending these studies …