Lipid nanoparticle (LNP) enables mRNA delivery for cancer therapy

Y Zong, Y Lin, T Wei, Q Cheng - Advanced Materials, 2023 - Wiley Online Library
Messenger RNA (mRNA) has received great attention in the prevention and treatment of
various diseases due to the success of coronavirus disease 2019 (COVID‐19) mRNA …

Stimuli-responsive polymer-based nanosystems for cancer theranostics

D Wei, Y Sun, H Zhu, Q Fu - ACS nano, 2023 - ACS Publications
Stimuli-responsive polymers can respond to internal stimuli, such as reactive oxygen
species (ROS), glutathione (GSH), and pH, biological stimuli, such as enzymes, and external …

[HTML][HTML] Tumor-associated macrophage subsets: shaping polarization and targeting

Q Zhang, M Sioud - International journal of molecular sciences, 2023 - mdpi.com
The tumor microenvironment (TME) is a critical regulator of tumor growth, progression, and
metastasis. Among the innate immune cells recruited to the tumor site, macrophages are the …

Living leukocyte‐based drug delivery systems

Y Chen, D Qin, J Zou, X Li, XD Guo, Y Tang… - Advanced …, 2023 - Wiley Online Library
Leukocytes play a vital role in immune responses, including defending against invasive
pathogens, reconstructing impaired tissue, and maintaining immune homeostasis. When the …

Biomaterials for in situ cell therapy

C Wang, S Wang, DD Kang, Y Dong - BMEMat, 2023 - Wiley Online Library
Cell therapy has revolutionized the treatment of various diseases, such as cancers, genetic
disorders, and autoimmune diseases. Currently, most cell therapy products rely on ex vivo …

Designing hydrogels for immunomodulation in cancer therapy and regenerative medicine

Z Zhang, C He, X Chen - Advanced Materials, 2024 - Wiley Online Library
The immune system not only acts as a defense against pathogen and cancer cells, but also
plays an important role in homeostasis and tissue regeneration. Targeting immune systems …

[HTML][HTML] Hydrogel-enabled, local administration and combinatorial delivery of immunotherapies for cancer treatment

A Erfani, AE Diaz, PS Doyle - Materials Today, 2023 - Elsevier
Throughout the last decade, interventions to engineer the immune system called
immunotherapy have revolutionized the fields of oncology and autoimmune disease …

[HTML][HTML] Advanced hitchhiking nanomaterials for biomedical applications

Y Wang, SK Sun, Y Liu, Z Zhang - Theranostics, 2023 - ncbi.nlm.nih.gov
Hitchhiking, a recently developed bio-inspired cargo delivery system, has been harnessed
for diverse applications. By leveraging the interactions between nanoparticles and …

Tumor microenvironment activated photoacoustic-fluorescence bimodal nanoprobe for precise chemo-immunotherapy and immune response tracing of glioblastoma

F Zeng, Z Fan, S Li, L Li, T Sun, Y Qiu, L Nie… - ACS nano, 2023 - ACS Publications
Synergistic therapy strategy and prognostic monitoring of glioblastoma's immune response
to treatment are crucial to optimize patient care and advance clinical outcomes. However …

Outer Membrane Vesicle‐Based Nanohybrids Target Tumor‐Associated Macrophages to Enhance Trained Immunity‐Related Vaccine‐Generated Antitumor Activity

J Liang, F Zhu, K Cheng, N Ma, X Ma… - Advanced …, 2023 - Wiley Online Library
Trained immunity refers to the innate immune system building memory‐like features in
response to subsequent infections and vaccinations. Compared with classical tumor …