Phosphoinositides are lipids involved in the vesicular transport of proteins and lipids
between the different compartments of eukaryotic cells. They act by recruiting and/or …

The plasma membrane and the underlying cortical actin cytoskeleton undergo continuous
dynamic interplay that is responsible for many essential aspects of cell physiology …

▪ Abstract Research in the past decade has revealed that many cytosolic proteins are
recruited to different cellular membranes to form protein-protein and lipid-protein interactions …

The trans-Golgi network (TGN) is an important cargo sorting station within the cell where
newly synthesized proteins are packaged into distinct transport carriers that are targeted to …

Eukaryotic cells have systems of internal organelles to synthesize lipids and membrane
proteins, to release secreted proteins, to take up nutrients and to degrade membrane-bound …

PH (pleckstrin homology) domains represent the 11th most common domain in the human
proteome. They are best known for their ability to bind phosphoinositides with high affinity …

Several pathogens—bacteria, viruses and parasites—must enter mammalian cells for
survival, replication and immune-system evasion. These pathogens generally make use of …

Phosphatidylinositolphosphates (PIP s) are phospholipids that contain a phosphorylated
inositol head group. PIP s represent a minor fraction of total phospholipids, but are involved …

The yeast Saccharomyces cerevisiae is one of the best characterized eukaryotic models.
The secretory pathway was the first trafficking pathway clearly understood mainly thanks to …

Phosphatidylinositol 3, 5‐bisphosphate (PtdIns (3, 5) P 2), made by Fab1p, is essential for
vesicle recycling from vacuole/lysosomal compartments and for protein sorting into …