Despite clinical and scientific advancements, heart failure is the major cause of morbidity
and mortality worldwide. Both mitochondrial dysfunction and inflammation contribute to the …

The kidney is a metabolically active organ that requires energy to drive processes such as
tubular reabsorption and secretion, and shows a decline in function with advancing age …

Circulating plasma proteins play key roles in human health and can potentially be used to
measure biological age, allowing risk prediction for age-related diseases, multimorbidity and …

Immunological health has been challenging to characterize but could be defined as the
absence of immune pathology. While shared features of some immune diseases and the …

The integration of quantitative trait loci (QTLs) with disease genome-wide association
studies (GWASs) has proven successful in prioritizing candidate genes at disease …

The metabolomic profile of aging is complex. Here, we analyse 325 nuclear magnetic
resonance (NMR) biomarkers from 250,341 UK Biobank participants, identifying 54 …

Beyond mere prognostication, optimal biomarkers of aging provide insights into qualitative
and quantitative features of biological aging and might, therefore, offer useful information for …

Parkinson's disease (PD) starts at the molecular and cellular level long before motor
symptoms appear, yet there are no early-stage molecular biomarkers for diagnosis …

Brain aging is a recognized risk factor for neurodegenerative diseases like Alzheimer's
disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS, Lou Gehrig's …

In an aging society, unveiling new anti-aging strategies to prevent and combat aging-related
diseases is of utmost importance. Mitochondria are the primary ATP production sites and key …