Microtubule-targeting agents (MTAs) such as paclitaxel and the vinca alkaloids are among
the most important medical weapons available to combat cancer. MTAs interfere with …

Microtubule-targeting agents (MTAs) constitute a diverse group of chemical compounds that
bind to microtubules and affect their properties and function. Disruption of microtubules …

Microtubules play a crucial role in multiple cellular functions including mitosis, cell signaling,
and organelle trafficking, which makes the microtubule an important target for cancer …

Highlights•Colchicine binding site inhibitors (CBSIs) emerge as new generations of tubulin
inhibitors.•CBSIs are less susceptible to multidrug resistance than FDA-approved tubulin …

Background: Although some benzimidazole-based anthelmintic drugs are found to possess
anticancer activity, their modes of binding interactions have not been reported. Methodology …

Molecular photoswitches transform light energy into reversible structural changes. Their
combination with known pharmacophores often allows for photomodulation of the biological …

Novel indazole and benzimidazole analogues were designed and synthesized as tubulin
inhibitors with potent antiproliferative activities. Among them, compound 12b exhibited the …

Although potential anticancer activities of benzimidazole-based anthelmintic drugs have
been approved by preclinical and clinical studies, modes of binding interactions have not …

Microtubule (MT)‐targeting agents are highly successful drugs as chemotherapeutic agents,
and this is attributed to their ability to target MT dynamics and interfere with critical cellular …

Tubulin-targeted chemotherapy has proven to be a successful and wide spectrum strategy
against solid and liquid malignancies. Therefore, new ways to modulate this essential …