Platelet-derived growth factor (PDGF) isoforms and PDGF receptors have important
functions in the regulation of growth and survival of certain cell types during embryonal …

The RET receptor tyrosine kinase is crucial for normal development but also contributes to
pathologies that reflect both the loss and the gain of RET function. Activation of RET occurs …

The tumour microenvironment may contribute to tumorigenesis owing to mechanical forces
such as fibrotic stiffness or mechanical pressure caused by the expansion of hyper …

Human malignancies are often the result of overexpressed and constitutively active receptor
and non-receptor tyrosine kinases, which ultimately lead to the mediation of key tumor …

Five-membered 1, 2, 4-oxadiazole heterocyclic ring has received considerable attention
because of its unique bioisosteric properties and an unusually wide spectrum of biological …

Since the discovery in 2012 of rearranged during transfection proto-oncogene gene (RET)
rearrangements in NSCLC, at least 12 different fusion variants have been identified, with …

The development of molecularly targeted anticancer agents relies on large panels of tumour-
specific preclinical models closely recapitulating the molecular heterogeneity observed in …

Leukemia is a malignancy of the hematopoietic system, and as its pathogenesis has
become better understood, three generations of tyrosine kinase inhibitors (TKIs) have been …

Medullary thyroid carcinoma (MTC) is a rare neuroendocrine tumor originating from the
parafollicular cells. The diagnostic and therapeutic strategies for the condition are different …

Differentiated thyroid cancers (DTC) are commonly and successfully treated with total
thyroidectomy plus/minus radioiodine therapy (RAI). Medullary thyroid cancer (MTC) is only …