Cross‐Coupling of Heteroarenes by C H Functionalization: Recent Progress towards Direct Arylation and Heteroarylation Reactions Involving Heteroarenes …
In recent years, transition metal‐catalyzed direct (hetero) arylation reactions of heteroarenes
with (hetero) aryl halides and pseudohalides have received significant attention as eco …
with (hetero) aryl halides and pseudohalides have received significant attention as eco …
Mechanistic Considerations in the Development and Use of Azine, Diazine and Azole N-Oxides in Palladium-Catalyzed Direct Arylation
K Fagnou - CH Activation, 2010 - Springer
Azines, diazines or thiazole N-oxides are highly reactive substrates in palladium-catalyzed
direct arylation reaction. For these reactions, the results are inconsistent with an SEAr …
direct arylation reaction. For these reactions, the results are inconsistent with an SEAr …
Palladium-Catalyzed Direct Arylation of Azine and Azole N-Oxides: Reaction Development, Scope and Applications in Synthesis
LC Campeau, DR Stuart, JP Leclerc… - Journal of the …, 2009 - ACS Publications
Palladium-catalyzed direct arylation reactions are described with a broad range of azine and
azole N-oxides. In addition to aspects of functional group compatibility, issues of …
azole N-oxides. In addition to aspects of functional group compatibility, issues of …
Catalytic Arylation of a C H Bond in Pyridine and Related Six‐Membered N‐Heteroarenes Using Organozinc Reagents
I Hyodo, M Tobisu, N Chatani - Chemistry–An Asian Journal, 2012 - Wiley Online Library
Despite significant advances in the catalytic direct arylation of heteroarenes, the application
of this reaction to pyridines has been met with limited success. An oxidative nucleophilic …
of this reaction to pyridines has been met with limited success. An oxidative nucleophilic …
Sodium channels and nociception: recent concepts and therapeutic opportunities
DS Krafte, AW Bannon - Current opinion in pharmacology, 2008 - Elsevier
Recent scientific advances have enhanced our understanding of the role voltage-gated
sodium channels play in pain sensation. Human data on Nav1. 7 show that gain-of-function …
sodium channels play in pain sensation. Human data on Nav1. 7 show that gain-of-function …
Discovery and Biological Evaluation of 5-Aryl-2-furfuramides, Potent and Selective Blockers of the Nav1.8 Sodium Channel with Efficacy in Models of Neuropathic …
ME Kort, I Drizin, RJ Gregg, MJC Scanio… - Journal of medicinal …, 2008 - ACS Publications
Nav1. 8 (also known as PN3) is a tetrodotoxin-resistant (TTx-r) voltage-gated sodium
channel (VGSC) that is highly expressed on small diameter sensory neurons and has been …
channel (VGSC) that is highly expressed on small diameter sensory neurons and has been …
Blockers of voltage-gated sodium channels for the treatment of central nervous system diseases
I Tarnawa, H Bolcskei, P Kocsis - Recent Patents on CNS Drug …, 2007 - ingentaconnect.com
Voltage gated sodium channels play important roles both in vital physiological functions and
several pathological processes of the central nervous system. Epilepsy, chronic pain …
several pathological processes of the central nervous system. Epilepsy, chronic pain …
Achievement of regioselectivity in transition metal-catalyzed direct C–H (hetero) arylation reactions of heteroarenes with one heteroatom through the use of removable …
The transition metal-catalyzed direct C–H (hetero) arylation reactions of heteroarenes are
currently one of the hottest topics of synthetic organic chemistry. In fact, these reactions …
currently one of the hottest topics of synthetic organic chemistry. In fact, these reactions …
Direct (hetero) arylation reactions of (hetero) arenes as tools for the step-and atom-economical synthesis of biologically active unnatural compounds including …
The significant number of papers and reviews published in this last decade testifies to the
utility of the transition-metal-catalyzed direct C–H (hetero) arylation reactions of (hetero) …
utility of the transition-metal-catalyzed direct C–H (hetero) arylation reactions of (hetero) …
Pd(II)-Catalyzed Ortho Arylation of 6-Arylpurines with Aryl Iodides via Purine-Directed C−H Activation: A New Strategy for Modification of 6-Arylpurine Derivatives
HM Guo, LL Jiang, HY Niu, WH Rao, L Liang… - Organic …, 2011 - ACS Publications
Purine is utilized as a new directing group for the Pd-catalyzed monoarylation of 6-
arylpurines with simple aryl iodides via C− H bond activation in good yields, providing a …
arylpurines with simple aryl iodides via C− H bond activation in good yields, providing a …