Idiopathic inflammatory myopathies (IIM), also known as myositis, are a heterogeneous
group of autoimmune disorders with varying clinical manifestations, treatment responses …

We investigated the relationship between oxidative stress and inflammatory myopathies. We
searched in the current literature the role of mitochondria and respiratory chain defects as …

Background Inclusion body myositis is an idiopathic inflammatory myopathy and the most
common myopathy affecting people older than 50 years. To date, there are no effective drug …

Objective To evaluate survival and associated comorbidities in inclusion body myositis (IBM)
in a population-based, case-control study. Methods We utilized the expanded Rochester …

Addressing the obstacles encountered by patients with IBM and the medical community
presents a multitude of challenges. Effectively surmounting these hurdles requires …

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are now known as
parts of a disease spectrum with common pathological features and genetic causes …

Idiopathic inflammatory myopathies (IIMs) are a group of acquired muscle diseases with
muscle inflammation, weakness, and other extra-muscular manifestations. IIMs can …

Background Inclusion body myositis is the most common progressive muscle wasting
disease in people older than 50 years, with no effective drug treatment. Arimoclomol is an …

Sporadic inclusion body myositis (sIBM) is an idiopathic inflammatory myopathy with
invasion of CD8 T cells in muscle and aggregation of proteins in the sarcoplasm. TDP-43 …

Valosin-containing protein (VCP) gene mutations have been associated with a rare
autosomal dominant, adult-onset progressive disease known as multisystem proteinopathy …