The adenosine monophosphate-activated protein kinase (AMPK) is a metabolic sensor of
energy metabolism at the cellular as well as whole-body level. It is activated by low energy …

Human survival has relied upon the ability to withstand starvation through energy storage,
the capacity to fight off infection by a proinflammatory immune response, and the ability to …

Exosomes are nanosized extracellular vesicles (EVs) that show great promise in tissue
regeneration and injury repair as mesenchymal stem cell (MSC). MSC has been shown to …

Skeletal muscle is a heterogeneous tissue composed of different fiber types. Studies
suggest that insulin-mediated glucose metabolism is different between muscle fiber types …

Insulin resistance is perceived as deleterious, associated with conditions as the metabolic
syndrome, type 2 diabetes mellitus and critical illness. However, insulin resistance is …

The human organism has tools to cope with metabolic challenges like starvation that are
crucial for survival. Lipolysis, lipid oxidation, ketone body synthesis, tailored endogenous …

Satellite cells can be isolated from skeletal muscle biopsies, activated to proliferating
myoblasts and differentiated into multinuclear myotubes in culture. These cell cultures …

Autophagy is a lysosome-dependent intracellular degradative pathway, which mediates the
cellular adaptation to nutrient and oxygen depletion as well as to oxidative and endoplasmic …

Key points Phosphorylation signature patterns on TBC1D1 and TBC1D4 proteins in the
insulin–glucose pathway were investigated in human skeletal muscle in response to …

Based primarily on evidence from rodent models fasting is currently believed to improve
metabolic health via activation of the AMPK-PGC-1α axis in skeletal muscle. However, it is …