The pancreatic β-cell plays a key role in glucose homeostasis by secreting insulin, the only
hormone capable of lowering the blood glucose concentration. Impaired insulin secretion …

In order to ensure normal body function, the human body is dependent on a tight control of
its blood glucose levels. This is accomplished by a highly sophisticated network of various …

The ability of the brain to store and process information relies on changing the strength of
connections between neurons. Synaptic facilitation is a form of short-term plasticity that …

During an action potential, Ca 2+ entering a presynaptic terminal triggers synaptic vesicle
exocytosis and neurotransmitter release in less than a millisecond. How does Ca 2+ …

It has been known for more than 70 years that synaptic strength is dynamically regulated in a
use-dependent manner. At synapses with a low initial release probability, closely spaced …

Upon entering a presynaptic terminal, an action potential opens Ca2+ channels, and
transiently increases the local Ca2+ concentration at the presynaptic active zone. Ca2+ then …

In forebrain neurons, knockout of synaptotagmin-1 blocks fast Ca 2+-triggered synchronous
neurotransmitter release but enables manifestation of slow Ca 2+-triggered asynchronous …

Ca2+ triggers many forms of exocytosis in different types of eukaryotic cells, for example
synaptic vesicle exocytosis in neurons, granule exocytosis in mast cells, and hormone …

The article presents a lecture on the molecular machinery of synaptic neurotransmitter
release. It discusses the speed of synaptic transmission of neurotransmitters, the molecular …

Fine-tuning of insulin release from pancreatic β-cells is essential to maintain blood glucose
homeostasis. Here, we report that insulin secretion is regulated by a circular RNA containing …