Glutamate and GABA imbalance following traumatic brain injury

RM Guerriero, CC Giza, A Rotenberg - Current neurology and …, 2015 - Springer
Traumatic brain injury (TBI) leads to multiple short-and long-term changes in neuronal
circuits that ultimately conclude with an imbalance of cortical excitation and inhibition …

Commonalities in epileptogenic processes from different acute brain insults: Do they translate?

P Klein, R Dingledine, E Aronica, C Bernard… - …, 2018 - Wiley Online Library
The most common forms of acquired epilepsies arise following acute brain insults such as
traumatic brain injury, stroke, or central nervous system infections. Treatment is effective for …

Advances in the development of biomarkers for epilepsy

A Pitkänen, W Löscher, A Vezzani, AJ Becker… - The Lancet …, 2016 - thelancet.com
Over 50 million people worldwide have epilepsy. In nearly 30% of these cases, epilepsy
remains unsatisfactorily controlled despite the availability of over 20 antiepileptic drugs …

Epileptogenesis

A Pitkänen, K Lukasiuk… - Cold Spring …, 2015 - perspectivesinmedicine.cshlp.org
Epileptogenesis is a chronic process that can be triggered by genetic or acquired factors,
and that can continue long after epilepsy diagnosis. In 2015, epileptogenesis is not a …

[HTML][HTML] Traumatic brain injury and epilepsy: underlying mechanisms leading to seizure

BP Lucke-Wold, L Nguyen, RC Turner, AF Logsdon… - Seizure, 2015 - Elsevier
Post-traumatic epilepsy continues to be a major concern for those experiencing traumatic
brain injury. Post-traumatic epilepsy accounts for 10–20% of epilepsy cases in the general …

IL‐1β associations with posttraumatic epilepsy development: A genetics and biomarker cohort study

ML Diamond, AC Ritter, MD Failla, JA Boles… - …, 2014 - Wiley Online Library
Objective Posttraumatic epilepsy (PTE) is a significant complication following traumatic brain
injury (TBI), yet the role of genetic variation in modulating PTE onset is unclear. We …

[HTML][HTML] Epilepsy related to traumatic brain injury

A Pitkänen, R Immonen - Neurotherapeutics, 2014 - Elsevier
Post-traumatic epilepsy accounts for 10–20% of symptomatic epilepsy in the general
population and 5% of all epilepsy. During the last decade, an increasing number of …

Post-traumatic epilepsy and comorbidities: advanced models, molecular mechanisms, biomarkers, and novel therapeutic interventions

VM Golub, DS Reddy - Pharmacological reviews, 2022 - ASPET
Post-traumatic epilepsy (PTE) is one of the most devastating long-term, network
consequences of traumatic brain injury (TBI). There is currently no approved treatment that …

Injury timing alters metabolic, inflammatory and functional outcomes following repeated mild traumatic brain injury

ZM Weil, KR Gaier, K Karelina - Neurobiology of disease, 2014 - Elsevier
Repeated head injuries are a major public health concern both for athletes, and members of
the police and armed forces. There is ample experimental and clinical evidence that there is …

[HTML][HTML] Novel approaches to prevent epileptogenesis after traumatic brain injury

CG Dulla, A Pitkänen - Neurotherapeutics, 2021 - Elsevier
Traumatic brain injury (TBI) is defined as an alteration in brain function or other evidence of
brain pathology caused by an external force. When epilepsy develops following TBI, it is …