The SKP1, CUL1, F-box protein (SCF) complex encompasses a group of 69 SCF E3
ubiquitin ligase complexes that primarily modify protein substrates with poly-ubiquitin chains …

Proteolysis targeting chimeras (PROTAC) are an emerging precision medicine strategy,
which targets key proteins for proteolytic degradation to ultimately induce cancer cell killing …

Chromosome instability (CIN), or progressive changes in chromosome numbers, is an
enabling feature of many cancers; however, the mechanisms giving rise to CIN remain …

SKP2 (S-phase kinase-associated protein 2) is a member of the F-box family of substrate-
recognition subunits in the SCF ubiquitin-protein ligase complexes. It is associated with …

As a core subunit of the SCF complex that promotes protein degradation through the 26S
proteasome, S-phase kinase-associated protein 1 (SKP1) plays important roles in multiple …

In the last decade, the ubiquitin proteasome system (UPS), in general, and E3 ubiquitin
ligases, in particular, have emerged as valid drug targets for the development of novel anti …

Abstract Skp1 (S-phase kinase-associated protein 1-Homo sapiens) is an adapter protein of
the SCF (Skp1-Cullin1-Fbox) complex, which links the constant components (Cul1-RBX) …

Skp1 is a conserved protein linking cullin-1 to F-box proteins in SCF (Skp1/Cullin-1/F-box
protein) E3 ubiquitin ligases, which modify protein substrates with polyubiquitin chains that …

Cullin-ring-ligases mediate protein polyubiquitination, a signal for degradation in the 26S
proteasome. The CRL1 class consists of Skp1/cullin-1/F-box protein/Rbx1 (SCF) complexes …

Skp2 is a member of the F-box family of proteins that serve as substrate-specific adaptors in
Skp1–CUL1–ROC1–F-box (SCF) E3 ubiquitin ligases. Skp2 (Fbxl1) directly binds to the …