The p38 signalling transduction pathway, a Mitogen-activated protein (MAP) kinase
pathway, plays an essential role in regulating many cellular processes including …

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Mesangial cells and their matrix form the central stalk of the glomerulus and are part of a
functional unit interacting closely with endothelial cells and podocytes. Alterations in one cell …

Overcome the toughest clinical challenges in nephrology with the new 9th edition of
Brenner/Rector's The Kidney! A brand-new editorial team of Drs. Maarten W. Taal, Glenn M …

It is estimated that over 10% of the adult population in developed countries have some
degree of chronic kidney disease (CKD). CKD is a progressive and irreversible deterioration …

Glomerular capillary pressure is thought to affect the structure and function of glomerular
cells. However, it is unknown whether podocytes are intrinsically sensitive to mechanical …

Diabetes and hypertension are the leading causes of chronic kidney disease and their
incidence is increasing at an alarming rate. Both are associated with impairments in the …

Renal fibrosis and tubular apoptosis are common mechanisms of progressive kidney
disease. In vitro studies have implicated the c-Jun amino-terminal kinase (JNK) pathway in …

Following an overview of the biochemistry of mitogen-activated protein kinase (MAPK)
pathways, the relevance of these signaling events to specific models of renal cell function …

Diabetic nephropathy is characterised by increased glomerular permeability to proteins,
thickening of the glomerular basement membrane, and excessive extracellular matrix …