[HTML][HTML] mTOR pathway: insights into an established pathway for brain mosaicism in epilepsy

A Gerasimenko, S Baldassari, S Baulac - Neurobiology of Disease, 2023 - Elsevier
The mechanistic target of rapamycin (mTOR) signaling pathway is an essential regulator of
numerous cellular activities such as metabolism, growth, proliferation, and survival. The …

Artificial intelligence for the detection of focal cortical dysplasia: Challenges in translating algorithms into clinical practice

L Walger, S Adler, K Wagstyl, L Henschel, B David… - …, 2023 - Wiley Online Library
Focal cortical dysplasias (FCDs) are malformations of cortical development and one of the
most common pathologies causing pharmacoresistant focal epilepsy. Resective …

Interpretable surface-based detection of focal cortical dysplasias: a Multi-centre Epilepsy Lesion Detection study

H Spitzer, M Ripart, K Whitaker, F D'Arco, K Mankad… - Brain, 2022 - academic.oup.com
One outstanding challenge for machine learning in diagnostic biomedical imaging is
algorithm interpretability. A key application is the identification of subtle epileptogenic focal …

Are AI language models such as ChatGPT ready to improve the care of individuals with epilepsy?

CM Boßelmann, C Leu, D Lal - Epilepsia (Series 4), 2023 - search.ebscohost.com
Keywords: epilepsy; machine learning; language model EN epilepsy machine learning
language model 1195 1199 5 05/11/23 20230501 NES 230501 Epilepsy is a neurological …

Artificial intelligence in epilepsy phenotyping

A Knight, T Gschwind, P Galer, GA Worrell, B Litt… - …, 2024 - Wiley Online Library
Artificial intelligence (AI) allows data analysis and integration at an unprecedented
granularity and scale. Here we review the technological advances, challenges, and future …

The clinical, imaging, pathological and genetic landscape of bottom-of-sulcus dysplasia

E Macdonald-Laurs, AEL Warren, P Francis… - Brain, 2024 - academic.oup.com
Bottom-of-sulcus dysplasia (BOSD) is increasingly recognized as a cause of drug-resistant,
surgically-remediable, focal epilepsy, often in seemingly MRI-negative patients. We describe …

[HTML][HTML] An open presurgery MRI dataset of people with epilepsy and focal cortical dysplasia type II

F Schuch, L Walger, M Schmitz, B David, T Bauer… - Scientific Data, 2023 - nature.com
Automated detection of lesions using artificial intelligence creates new standards in medical
imaging. For people with epilepsy, automated detection of focal cortical dysplasias (FCDs) is …

Expedited epilepsy surgery prior to drug resistance in children: a frontier worth crossing?

AT Hale, A Chari, RC Scott, J Helen Cross, CJ Rozzelle… - 2022 - academic.oup.com
Epilepsy surgery is an established safe and effective treatment for selected candidates with
drug-resistant epilepsy. In this opinion piece, we outline the clinical and experimental …

Artificial intelligence in epilepsy—applications and pathways to the clinic

A Lucas, A Revell, KA Davis - Nature Reviews Neurology, 2024 - nature.com
Artificial intelligence (AI) is rapidly transforming health care, and its applications in epilepsy
have increased exponentially over the past decade. Integration of AI into epilepsy …

Prevalence and Risk Factors for Pharmacoresistance in Children With Focal Cortical Dysplasia–Related Epilepsy

NT Cohen, P Chang, X You, A Zhang, KA Havens… - Neurology, 2022 - AAN Enterprises
Background and Objectives Focal cortical dysplasia (FCD) is the most common cause of
surgically remediable epilepsy in children. Little is known about the risk factors for the timing …