Rapamycin: one drug, many effects
J Li, SG Kim, J Blenis - Cell metabolism, 2014 - cell.com
The mammalian target of rapamycin (mTOR) signaling pathway is a master regulator of cell
growth and metabolism. Deregulation of the mTOR pathway has been implicated in a …
growth and metabolism. Deregulation of the mTOR pathway has been implicated in a …
The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation
The Ras-extracellular signal-regulated kinase (Ras-ERK) and phosphatidylinositol 3-kinase-
mammalian target of rapamycin (PI3K-mTOR) signaling pathways are the chief mechanisms …
mammalian target of rapamycin (PI3K-mTOR) signaling pathways are the chief mechanisms …
PI3K signalling: the path to discovery and understanding
B Vanhaesebroeck, L Stephens… - Nature reviews Molecular …, 2012 - nature.com
Over the past two decades, our understanding of phospoinositide 3-kinases (PI3Ks) has
progressed from the identification of an enzymatic activity associated with growth factors …
progressed from the identification of an enzymatic activity associated with growth factors …
[HTML][HTML] AKT and ERK dual inhibitors: the way forward?
Z Cao, Q Liao, M Su, K Huang, J Jin, D Cao - Cancer letters, 2019 - Elsevier
Abstract Phosphatidylinositol 3-kinase (PI3K)/AKT pathway regulates cell growth,
proliferation, survival, mobility and invasion. Mitogen-activated protein kinase …
proliferation, survival, mobility and invasion. Mitogen-activated protein kinase …
Role of platelet-derived growth factors in physiology and medicine
J Andrae, R Gallini, C Betsholtz - Genes & development, 2008 - genesdev.cshlp.org
Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) have served as
prototypes for growth factor and receptor tyrosine kinase function for more than 25 years …
prototypes for growth factor and receptor tyrosine kinase function for more than 25 years …
Upstream and downstream of mTOR
N Hay, N Sonenberg - Genes & development, 2004 - genesdev.cshlp.org
The evolutionarily conserved checkpoint protein kinase, TOR (target of rapamycin), has
emerged as a major effector of cell growth and proliferation via the regulation of protein …
emerged as a major effector of cell growth and proliferation via the regulation of protein …
New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
LC Cantley, BG Neel - … of the National Academy of Sciences, 1999 - National Acad Sciences
The most recently discovered PTEN tumor suppressor gene has been found to be defective
in a large number of human cancers. In addition, germ-line mutations in PTEN result in the …
in a large number of human cancers. In addition, germ-line mutations in PTEN result in the …
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway
The S/T-protein kinases activated by phosphoinositide 3-kinase (PI3K) regulate a myriad of
cellular processes. Here, we show that an approach using a combination of biochemistry …
cellular processes. Here, we show that an approach using a combination of biochemistry …
Regulation of neuronal survival by the serine-threonine protein kinase Akt
A signaling pathway was delineated by which insulin-like growth factor 1 (IGF-1) promotes
the survival of cerebellar neurons. IGF-1 activation of phosphoinositide 3-kinase (PI3-K) …
the survival of cerebellar neurons. IGF-1 activation of phosphoinositide 3-kinase (PI3-K) …
Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction
BMT Burgering, PJ Coffer - Nature, 1995 - nature.com
A serine/threonine kinase, named protein kinase B (PKB) 1 for its sequence homology to
both protein kinase A and C, has previously been isolated. PKB, which is identical to the …
both protein kinase A and C, has previously been isolated. PKB, which is identical to the …