Regulation of ketone body metabolism and the role of PPARα

M Grabacka, M Pierzchalska, M Dean… - International journal of …, 2016 - mdpi.com
Ketogenesis and ketolysis are central metabolic processes activated during the response to
fasting. Ketogenesis is regulated in multiple stages, and a nuclear receptor peroxisome …

Mitochondria: The ketogenic diet—A metabolism-based therapy

S Vidali, S Aminzadeh, B Lambert, T Rutherford… - The international journal …, 2015 - Elsevier
Mitochondria are the energy-producing organelles of the cell, generating ATP via oxidative
phosphorylation mainly by using pyruvate derived from glycolytic processing of glucose …

Effectiveness of federated learning and CNN ensemble architectures for identifying brain tumors using MRI images

M Islam, MT Reza, M Kaosar, MZ Parvez - Neural Processing Letters, 2023 - Springer
Medical institutions often revoke data access due to the privacy concern of patients.
Federated Learning (FL) is a collaborative learning paradigm that can generate an unbiased …

Acetate revisited: a key biomolecule at the nexus of metabolism, epigenetics, and oncogenesis–part 2: acetate and ACSS2 in health and disease

JR Moffett, N Puthillathu, R Vengilote… - Frontiers in …, 2020 - frontiersin.org
Acetate, the shortest chain fatty acid, has been implicated in providing health benefits
whether it is derived from the diet or is generated from microbial fermentation of fiber in the …

Glioblastoma microenvironment and cellular interactions

CB Crivii, AB Boșca, CS Melincovici, AM Constantin… - Cancers, 2022 - mdpi.com
Simple Summary This paper summarizes the crosstalk between tumor/non-tumor cells and
other elements of the glioblastoma (GB) microenvironment. In tumor pathology, glial cells …

Reactive oxygen species: Do they play a role in adaptive immunity?

EY Bassoy, M Walch, D Martinvalet - Frontiers in Immunology, 2021 - frontiersin.org
The immune system protects the host from a plethora of microorganisms and toxins through
its unique ability to distinguish self from non-self. To perform this delicate but essential task …

Enhanced immunity in a mouse model of malignant glioma is mediated by a therapeutic ketogenic diet

DM Lussier, EC Woolf, JL Johnson, KS Brooks… - BMC cancer, 2016 - Springer
Background Glioblastoma multiforme is a highly aggressive brain tumor with a poor
prognosis, and advances in treatment have led to only marginal increases in overall …

Mitochondrial substrate-level phosphorylation as energy source for glioblastoma: review and hypothesis

C Chinopoulos, TN Seyfried - ASN neuro, 2018 - journals.sagepub.com
Glioblastoma multiforme (GBM) is the most common and malignant of the primary adult brain
cancers. Ultrastructural and biochemical evidence shows that GBM cells exhibit …

Therapeutic benefit of combining calorie-restricted ketogenic diet and glutamine targeting in late-stage experimental glioblastoma

P Mukherjee, ZM Augur, M Li, C Hill… - Communications …, 2019 - nature.com
Glioblastoma (GBM) is an aggressive primary human brain tumour that has resisted effective
therapy for decades. Although glucose and glutamine are the major fuels that drive GBM …

[HTML][HTML] Epigenetic modulation of metabolism in glioblastoma

Z Dong, H Cui - Seminars in cancer biology, 2019 - Elsevier
Epigenetic and metabolic alterations incancer cells are highly associated. Glioblastoma
multiforme (GBM) is a complicated pathological process with dysregulated methylation and …