Blood and bone: two tissues whose fates are intertwined to create the hematopoietic stem-cell niche
RS Taichman - Blood, 2005 - ashpublications.org
The mechanisms of bone and blood formation have traditionally been viewed as distinct,
unrelated processes, but compelling evidence suggests that they are intertwined. Based on …
unrelated processes, but compelling evidence suggests that they are intertwined. Based on …
Mesenchymal stem cells as therapeutics and vehicles for gene and drug delivery
CD Porada, G Almeida-Porada - Advanced drug delivery reviews, 2010 - Elsevier
Mesenchymal stem cells (MSCs) possess a set of several fairly unique properties which
make them ideally suited both for cellular therapies/regenerative medicine, and as vehicles …
make them ideally suited both for cellular therapies/regenerative medicine, and as vehicles …
Local irradiation not only induces homing of human mesenchymal stem cells at exposed sites but promotes their widespread engraftment to multiple organs: a study of …
S François, M Bensidhoum, M Mouiseddine… - Stem …, 2006 - academic.oup.com
Mesenchymal stem cells (MSCs) have been shown to migrate to various tissues. There is
little information on the fate and potential therapeutic efficacy of the reinfusion of MSCs …
little information on the fate and potential therapeutic efficacy of the reinfusion of MSCs …
Human mesenchymal stem cells home specifically to radiation-injured tissues in a non-obese diabetes/severe combined immunodeficiency mouse model
M Mouiseddine, S Francois, A Semont… - The British journal of …, 2007 - academic.oup.com
The therapeutic potential of bone marrow-derived human mesenchymal stem cells (hMSC)
has recently been brought into the spotlights of many fields of research. One possible …
has recently been brought into the spotlights of many fields of research. One possible …
[HTML][HTML] Cotransplantation of stroma results in enhancement of engraftment and early expression of donor hematopoietic stem cells in utero
G Almeida-Porada, AW Flake, HA Glimp… - Experimental …, 1999 - Elsevier
Although promising, clinical and experimental efforts at in utero hematopoietic stem cell
(HSC) transplantation currently are limited by minimal donor cell engraftment and lack of …
(HSC) transplantation currently are limited by minimal donor cell engraftment and lack of …
In utero stem cell transplantation and gene therapy: rationale, history, and recent advances toward clinical application
G Almeida-Porada, A Atala, CD Porada - Molecular Therapy-Methods & …, 2016 - cell.com
Recent advances in high-throughput molecular testing have made it possible to diagnose
most genetic disorders relatively early in gestation with minimal risk to the fetus. These …
most genetic disorders relatively early in gestation with minimal risk to the fetus. These …
The hematopoietic system in the context of regenerative medicine
CD Porada, AJ Atala, G Almeida-Porada - Methods, 2016 - Elsevier
Hematopoietic stem cells (HSC) represent the prototype stem cell within the body. Since
their discovery, HSC have been the focus of intensive research, and have proven invaluable …
their discovery, HSC have been the focus of intensive research, and have proven invaluable …
[HTML][HTML] Bone marrow stem cells and liver regeneration
G Almeida-Porada, ED Zanjani, CD Porada - Experimental hematology, 2010 - Elsevier
Development of new approaches to treat patients with hepatic diseases that can eliminate
the need for liver transplantation is imperative. Use of cell therapy as a means of …
the need for liver transplantation is imperative. Use of cell therapy as a means of …
[HTML][HTML] Phenotypic correction of hemophilia A in sheep by postnatal intraperitoneal transplantation of FVIII-expressing MSC
CD Porada, C Sanada, CJ Kuo, E Colletti… - Experimental …, 2011 - Elsevier
We recently re-established a line of sheep that accurately mimics the clinical symptoms and
genetics of severe hemophilia A (HA). Here, we tested a novel, nonablative transplantation …
genetics of severe hemophilia A (HA). Here, we tested a novel, nonablative transplantation …
[HTML][HTML] Concepts for the clinical use of stem cells in equine medicine
Stem cells from various tissues hold great promise for their therapeutic use in horses, but so
far efficacy or proof-of-principle has not been established. The basic characteristics and …
far efficacy or proof-of-principle has not been established. The basic characteristics and …