Blood and bone: two tissues whose fates are intertwined to create the hematopoietic stem-cell niche

RS Taichman - Blood, 2005 - ashpublications.org
The mechanisms of bone and blood formation have traditionally been viewed as distinct,
unrelated processes, but compelling evidence suggests that they are intertwined. Based on …

Mesenchymal stem cells as therapeutics and vehicles for gene and drug delivery

CD Porada, G Almeida-Porada - Advanced drug delivery reviews, 2010 - Elsevier
Mesenchymal stem cells (MSCs) possess a set of several fairly unique properties which
make them ideally suited both for cellular therapies/regenerative medicine, and as vehicles …

Local irradiation not only induces homing of human mesenchymal stem cells at exposed sites but promotes their widespread engraftment to multiple organs: a study of …

S François, M Bensidhoum, M Mouiseddine… - Stem …, 2006 - academic.oup.com
Mesenchymal stem cells (MSCs) have been shown to migrate to various tissues. There is
little information on the fate and potential therapeutic efficacy of the reinfusion of MSCs …

Human mesenchymal stem cells home specifically to radiation-injured tissues in a non-obese diabetes/severe combined immunodeficiency mouse model

M Mouiseddine, S Francois, A Semont… - The British journal of …, 2007 - academic.oup.com
The therapeutic potential of bone marrow-derived human mesenchymal stem cells (hMSC)
has recently been brought into the spotlights of many fields of research. One possible …

[HTML][HTML] Cotransplantation of stroma results in enhancement of engraftment and early expression of donor hematopoietic stem cells in utero

G Almeida-Porada, AW Flake, HA Glimp… - Experimental …, 1999 - Elsevier
Although promising, clinical and experimental efforts at in utero hematopoietic stem cell
(HSC) transplantation currently are limited by minimal donor cell engraftment and lack of …

In utero stem cell transplantation and gene therapy: rationale, history, and recent advances toward clinical application

G Almeida-Porada, A Atala, CD Porada - Molecular Therapy-Methods & …, 2016 - cell.com
Recent advances in high-throughput molecular testing have made it possible to diagnose
most genetic disorders relatively early in gestation with minimal risk to the fetus. These …

The hematopoietic system in the context of regenerative medicine

CD Porada, AJ Atala, G Almeida-Porada - Methods, 2016 - Elsevier
Hematopoietic stem cells (HSC) represent the prototype stem cell within the body. Since
their discovery, HSC have been the focus of intensive research, and have proven invaluable …

[HTML][HTML] Bone marrow stem cells and liver regeneration

G Almeida-Porada, ED Zanjani, CD Porada - Experimental hematology, 2010 - Elsevier
Development of new approaches to treat patients with hepatic diseases that can eliminate
the need for liver transplantation is imperative. Use of cell therapy as a means of …

[HTML][HTML] Phenotypic correction of hemophilia A in sheep by postnatal intraperitoneal transplantation of FVIII-expressing MSC

CD Porada, C Sanada, CJ Kuo, E Colletti… - Experimental …, 2011 - Elsevier
We recently re-established a line of sheep that accurately mimics the clinical symptoms and
genetics of severe hemophilia A (HA). Here, we tested a novel, nonablative transplantation …

[HTML][HTML] Concepts for the clinical use of stem cells in equine medicine

TG Koch, LC Berg, DH Betts - The Canadian veterinary journal, 2008 - ncbi.nlm.nih.gov
Stem cells from various tissues hold great promise for their therapeutic use in horses, but so
far efficacy or proof-of-principle has not been established. The basic characteristics and …