Physical forces have a crucial role in tumor progression and cancer treatment. The
application of principles of engineering and physical sciences to oncology has provided …

Metastasis is a multistep process in which tumor extracellular matrix (ECM) and cancer cell
cytoskeleton interactions are pivotal. ECM is connected, through integrins, to the cell's …

Tumors generate physical forces during growth and progression. These physical forces are
able to compress blood and lymphatic vessels, reducing perfusion rates and creating …

Solid tumors are characterized by an abnormal stroma that contributes to the development of
biomechanical abnormalities in the tumor microenvironment. In particular, these …

It is generally accepted that fibroblast-to-myofibroblast differentiation represents a key event
during wound healing and tissue repair. The high contractile force generated by …

Glioblastoma multiforme (GBM) is a malignant astrocytoma of the central nervous system
associated with a median survival time of 15 months, even with aggressive therapy. This …

E-cadherin-based cell-cell adhesions are dynamically and locally regulated in many
essential processes, including embryogenesis, wound healing and tissue organization, with …

Glioblastoma multiforme (GBM) is a malignant brain tumor characterized by diffuse
infiltration of single cells into the brain parenchyma, which is a process that relies in part on …

Collagen is the most abundant extracellular-network-forming protein in animal biology and
is important in both natural and artificial tissues, where it serves as a material of great …

Glioblastoma (GBM) is the most common and aggressive form of primary brain tumor with a
median survival of 12–15 months, and the mechanisms underlying GBM tumor progression …