Assembly of the mycobacterial cell wall

M Jankute, JAG Cox, J Harrison… - Annual review of …, 2015 - annualreviews.org
Mycobacterium tuberculosis remains one of the most successful bacterial pathogens,
claiming over 1.3 million lives worldwide in 2013. The emergence of multidrug-resistant and …

Mycobacterial cell wall biosynthesis: a multifaceted antibiotic target

KA Abrahams, GS Besra - Parasitology, 2018 - cambridge.org
Mycobacterium tuberculosis (Mtb), the etiological agent of tuberculosis (TB), is recognized
as a global health emergency as promoted by the World Health Organization. Over 1 million …

The thick waxy coat of mycobacteria, a protective layer against antibiotics and the host's immune system

SM Batt, DE Minnikin, GS Besra - Biochemical Journal, 2020 - portlandpress.com
Tuberculosis, caused by the pathogenic bacterium Mycobacterium tuberculosis (Mtb), is the
leading cause of death from an infectious disease, with a mortality rate of over a million …

Phylogenetic framework and molecular signatures for the main clades of the phylum Actinobacteria

B Gao, RS Gupta - Microbiology and molecular biology reviews, 2012 - Am Soc Microbiol
The phylum Actinobacteria harbors many important human pathogens and also provides
one of the richest sources of natural products, including numerous antibiotics and other …

Lipoarabinomannan and related glycoconjugates: structure, biogenesis and role in Mycobacterium tuberculosis physiology and host–pathogen interaction

AK Mishra, NN Driessen, BJ Appelmelk… - FEMS microbiology …, 2011 - academic.oup.com
Approximately one third of the world's population is infected with Mycobacterium
tuberculosis, the causative agent of tuberculosis. This bacterium has an unusual lipid-rich …

Chemical Synthesis of Cell Wall Constituents of Mycobacterium tuberculosis

M Holzheimer, J Buter, AJ Minnaard - Chemical reviews, 2021 - ACS Publications
The pathogen Mycobacterium tuberculosis (Mtb), causing tuberculosis disease, features an
extraordinary thick cell envelope, rich in Mtb-specific lipids, glycolipids, and glycans. These …

Biogenesis of the cell wall and other glycoconjugates of Mycobacterium tuberculosis

D Kaur, ME Guerin, H Škovierová, PJ Brennan… - Advances in applied …, 2009 - Elsevier
The re-emergence of tuberculosis in its present-day manifestations–single, multiple and
extensive drug-resistant forms and as HIV-TB coinfections–has resulted in renewed …

The cell envelope glycoconjugates of Mycobacterium tuberculosis

SK Angala, JM Belardinelli, E Huc-Claustre… - Critical reviews in …, 2014 - Taylor & Francis
Tuberculosis (TB) remains the second most common cause of death due to a single
infectious agent. The cell envelope of Mycobacterium tuberculosis (Mtb), the causative agent …

A Mycobacterium tuberculosis fingerprint in human breath allows tuberculosis detection

SF Mosquera-Restrepo, S Zuberogoïtia… - Nature …, 2022 - nature.com
An estimated one-third of tuberculosis (TB) cases go undiagnosed or unreported. Sputum
samples, widely used for TB diagnosis, are inefficient at detecting infection in children and …

Identification and characterization of endo-α-, exo-α-, and exo-β-d-arabinofuranosidases degrading lipoarabinomannan and arabinogalactan of mycobacteria

M Shimokawa, A Ishiwata, T Kashima… - Nature …, 2023 - nature.com
The cell walls of pathogenic and acidophilic bacteria, such as Mycobacterium tuberculosis
and Mycobacterium leprae, contain lipoarabinomannan and arabinogalactan. These …