Endurance exercise is a widely accessible, low-cost intervention with a variety of benefits to
multiple organ systems. Exercise improves multiple indices of physical performance and …

The ubiquitin-proteasome system (UPS) has been implicated in neurodegenerative
diseases based on the presence of deposits consisting of ubiquitylated proteins in affected …

The discovery that expansion of unstable repeats can cause a variety of neurological
disorders has changed the landscape of disease-oriented research for several forms of …

In eukaryotes, the core promoter serves as a platform for the assembly of transcription
preinitiation complex (PIC) that includes TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH, and RNA …

The spinocerebellar ataxias type 1 (SCA1), 2 (SCA2), 3 (SCA3), 6 (SCA6) and 7 (SCA7) are
genetically defined autosomal dominantly inherited progressive cerebellar ataxias (ADCAs) …

Histone deacetylases (HDACs)—enzymes that affect the acetylation status of histones and
other important cellular proteins—have been recognized as potentially useful therapeutic …

Transcription in eukaryotes is a tightly regulated, multistep process. Gene-specific
transcriptional activators, several different co-activators and general transcription factors are …

The polyglutamine (polyQ) diseases are a group of neurodegenerative disorders caused by
expanded cytosine–adenine–guanine (CAG) repeats encoding a long polyQ tract in the …

Transcriptional activators, several different coactivators, and general transcription factors are
necessary to access specific loci in the dense chromatin structure to allow precise initiation …

Amyotrophic lateral sclerosis (ALS) is a spontaneous, relentlessly progressive motor neuron
disease, usually resulting in death from respiratory failure within 3 years. Variation in the …