Insights into inflammasome regulation: cellular, molecular, and pathogenic control of inflammasome activation

N Challagundla, B Saha, R Agrawal-Rajput - Immunologic Research, 2022 - Springer
Maintenance of immune homeostasis is an intricate process wherein inflammasomes play a
pivotal role by contributing to innate and adaptive immune responses. Inflammasomes are …

Interactions of antithrombotic herbal medicines with Western cardiovascular drugs

HL Zuo, KG Linghu, YL Wang, KM Liu, Y Gao… - Pharmacological …, 2020 - Elsevier
Thrombotic events act as a critical factor that interferes with Cardiovascular Diseases
(CVDs), and antithrombotic herbal medicine is a long-standing controversial issue. Although …

Changes in the neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios before and after percutaneous coronary intervention and their impact on the prognosis of …

J Sheng, N Liu, F He, C Cheng, S Shen, Y Sun - Clinics, 2021 - SciELO Brasil
OBJECTIVES: This study aimed to prospectively observe the changes in the neutrophil-to-
lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) before and after …

Meta-inflammation and new anti-diabetic drugs: a new chance to knock down residual cardiovascular risk

A d'Aiello, A Bonanni, R Vinci, D Pedicino… - International Journal of …, 2023 - mdpi.com
Type 2 diabetes mellitus (DM) represents, with its macro and microvascular complications,
one of the most critical healthcare issues for the next decades. Remarkably, in the context of …

Inflammasome: structure, biological functions, and therapeutic targets

Y Dai, J Zhou, C Shi - MedComm, 2023 - Wiley Online Library
Inflammasomes are a group of protein complex located in cytoplasm and assemble in
response to a wide variety of pathogen‐associated molecule patterns, damage‐associated …

[HTML][HTML] Developmental endothelial locus-1 in cardiovascular and metabolic diseases: A promising biomarker and therapeutic target

M Zhao, Z Zheng, C Li, J Wan, M Wang - Frontiers in immunology, 2022 - frontiersin.org
Cardiovascular and metabolic diseases (CVMDs) are a leading cause of death worldwide
and impose a major socioeconomic burden on individuals and healthcare systems …

Promises and challenges of targeting inflammation to treat cardiovascular disease: the post-CANTOS era

LM Biasucci, D Pedicino, G Liuzzo - European Heart Journal, 2020 - academic.oup.com
This editorial refers to 'Residual inflammatory risk associated with interleukin-18 and
interleukin-6 after successful interleukin-1b inhibition with canakinumab: further rationale for …

Metabolism-inflammasome crosstalk shapes innate and adaptive immunity

J Wu, X Sun, P Jiang - Cell Chemical Biology, 2024 - cell.com
Inflammasomes are a central component of innate immunity and play a vital role in
regulating innate immune response. Activation of inflammasomes is also indispensable for …

Trained Innate Immunity in Animal Models of Cardiovascular Diseases

P Kleimann, LM Irschfeld, M Grandoch… - International Journal of …, 2024 - mdpi.com
Acquisition of immunological memory is an important evolutionary strategy that evolved to
protect the host from repetitive challenges from infectious agents. It was believed for a long …

A novel monocyte subset as a unique signature of atherosclerotic plaque rupture

R Vinci, D Pedicino, A Bonanni, A D'Aiello… - Frontiers in Cell and …, 2021 - frontiersin.org
The evaluation of monocyte subset distribution among acute coronary syndrome (ACS)
patients according to culprit coronary plaque morphology has never been explored. We …