Purpose. The increasing incidence of colorectal cancer (CRC) in the past three decades in
Iran has made it a major public health burden. This study aimed to report its epidemiologic …

Although the incidence of colorectal cancer in Iranian older age subjects is currently very
low compared to Western population, the younger generation is experiencing an …

Colorectal cancer (CRC) is associated with lifestyle factors that affect insulin/IGF signaling,
of which the insulin receptor substrate 1 (IRS1) is a key transducer. We investigated …

Colorectal cancer (CRC) is one of the most common and fatal types of cancer. Inflammation
promotes CRC development, however, the underlying etiological factors are unknown …

The majority of “serrated pathway” colorectal cancers have mutation of the BRAF oncogene
and display the CpG island methylator phenotype (CIMP). Half these cancers have …

PURPOSE Next Generation Sequencing (NGS) is currently used to establish mutational
profiles in many multigene diseases such as colorectal cancer (CRC), which is on the rise in …

Majority of colorectal cancer (CRC) patients are presented with advanced disease at
diagnosis, particularly in cases of proximal CRCs. Little is known about the relationship …

Juvenile breast cancer is rare and poorly known. We studied a series of five breast cancer
patients diagnosed within 25 years of age that included two adolescents, 12-and 15-years …

Abstract Background/Aims: Colorectal cancer (CRC) is mainly caused by chromosomal
instability (CIN) and microsatellite instability (MSI). The RAS and RAF genes are essential …

Abstract Women from Pakistan and India are more often diagnosed with early-onset breast
cancer than Caucasian women. Given that only 12% of Pakistani women diagnosed with …