The COVID-19 pandemic has transformed vaccinology. Rapid deployment of mRNA
vaccines has saved countless lives. However, these platforms have inherent limitations …

Generating potent neutralizing antibodies is a unifying goal of next-generation vaccines. In
this issue of Immunity, Ols et al. show that multivalent nanoparticle vaccines displaying RSV …

Although protein subunit vaccines generally have acceptable safety profiles with precise
antigenic content, limited immunogenicity can lead to unsatisfactory humoral and cellular …

Nanoparticle vaccines have firmly established themselves as a cornerstone of modern
immunization strategies, with a compelling history that traces its origins back to their …

Developing a mucosal vaccine against SARS-CoV-2 is critical for combatting the epidemic.
Here, we investigated long-term immune responses and protection against SARS-CoV-2 for …

纳米颗粒疫苗自1981 年首次应用于人体以来, 经历逾40 年的发展历程, 在临床应用方面已取得
了极大成功. 尤其是在乙型肝炎病毒(hepatitis B virus, HBV), 人乳头瘤病毒(human …

Middle East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic betacoronavirus
that causes severe and often lethal respiratory illness in humans. The MERS-CoV spike (S) …

Nanoparticle vaccines displaying mosaic receptor-binding domains (RBDs) or spike (S) from
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or other sarbecoviruses are …

Class-switched neutralizing antibody (nAb) production is rapidly induced upon many viral
infections. However, due to the presence of multiple components in typical virions, the …

The durability of an antibody (Ab) response is highly important for antiviral vaccines.
However, due to the complex compositions of natural virions, the molecular determinants of …